Structure of PDB 8t9a Chain B Binding Site BS01

Receptor Information
>8t9a Chain B (length=379) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPVKRSLVYYLKNREVRLQNETSYSRVLHGYAAQQLPSLLKEREFHLGTL
NKVFASQWLNHRQVVCGTKCNTLFVVDVQTSQITKIPILKDCGIHAIELN
PSRTLLATGGDNPNSLAIYRLPTLDPVCVGDDGHKDWIFSIAWISDTMAV
SGSRDGSMGLWEVTDDVLTKSDARHNVSRVPVYAHITHKALKDINCKVRA
LAFNNKNKELGAVSLDGYFHLWKAENTLSKLLSTKLPYCRENVCLAYGSE
WSVYAVGSQAHVSFLDPRQPSYNVKSVCSRERGSGIRSVSFYEHIITVGT
GQGSLLFYDIRAQRFLEENLKLTTGKGWLNHDETWRNYFSDIFPNAVYTH
CYDSSGTKLFVAGGPLPSGLHGNYAGLWS
Ligand information
Receptor-Ligand Complex Structure
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PDB8t9a CryoEM structure of human DDB1-DCAF12 in complex with MAGEA3
Resolution3.17 Å
Binding residue
(original residue number in PDB)		K91 F93 K108 H144 R344 P441 S442
Binding residue
(residue number reindexed from 1)		K52 F54 K69 H95 R287 P367 S368
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:1990756 ubiquitin-like ligase-substrate adaptor activity
Biological Process
GO:0010506 regulation of autophagy
GO:0016567 protein ubiquitination
GO:0042110 T cell activation
GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0080008 Cul4-RING E3 ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8t9a, PDBe:8t9a, PDBj:8t9a
PDBsum8t9a
PubMed
UniProtQ5T6F0|DCA12_HUMAN DDB1- and CUL4-associated factor 12 (Gene Name=DCAF12)

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