Structure of PDB 8t75 Chain B Binding Site BS01

Receptor Information
>8t75 Chain B (length=132) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHK
GKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQ
KFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8t75 Chain B Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8t75 Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties
Resolution2.65 Å
Binding residue
(original residue number in PDB)		H139 C165 C168 C184
Binding residue
(residue number reindexed from 1)		H83 C109 C112 C128
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Gene Ontology
Biological Process
GO:0007165 signal transduction

View graph for
Biological Process
External links
PDB RCSB:8t75, PDBe:8t75, PDBj:8t75
PDBsum8t75
PubMed38354232
UniProtP04049|RAF1_HUMAN RAF proto-oncogene serine/threonine-protein kinase (Gene Name=RAF1)

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