Structure of PDB 8sw5 Chain B Binding Site BS01

Receptor Information
>8sw5 Chain B (length=293) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLEL
EAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETIC
LLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDC
FNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLL
WSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGY
EFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKP
Ligand information
>8sw5 Chain D (length=22) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
KGILKKTVTWPEEGKLREYFYF
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8sw5 A Protein Phosphatase 1 specific phosphatase targeting peptide (PhosTAP) to identify the PP1 phosphatome
Resolution2.39 Å
Binding residue
(original residue number in PDB)		Q49 E54 L55 E56 R74 Y78 N86 E116 N117 D166 K168 D242 D253 Y255 F257 R261 L289 M290 C291 F293 Q294 I295 L296 K297 P298
Binding residue
(residue number reindexed from 1)		Q44 E49 L50 E51 R69 Y73 N81 E111 N112 D161 K163 D237 D248 Y250 F252 R256 L284 M285 C286 F288 Q289 I290 L291 K292 P293
Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
External links
PDB RCSB:8sw5, PDBe:8sw5, PDBj:8sw5
PDBsum8sw5
PubMed
UniProtP62136|PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (Gene Name=PPP1CA)

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