Structure of PDB 8sly Chain B Binding Site BS01

Receptor Information
>8sly Chain B (length=591) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FDRDRLFSVVSRGVPEELTGLLEYLRWNSKYLTDSAYTEGSTGKTCLMKA
VLNLACIMPLLQIDKDSGNPKLLVNAQCTDEFYQGHSALHIAIEKRSLQC
VKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYL
LENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGA
RLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQREFSGPYQPLSRK
FTEWCYGPVRVSLYDLSSVDSWEKNSVLEIIAFHCKSPNRHRMVVLEPLN
KLLQEKWDRLVSRFFFNFACYLVYMFIFTVVAYHQPSMLLLGHILILLGG
IYLLLGQLWYFWRRRLFIWISFMDSYFEILFLLQALLTVLSQVLRFMETE
WYLPLLVLSLVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYL
VFLFGFAVALVSLSRRSILDASLELFKFTIGMGELAFQEQLRFRGVVLLL
LLAYVLLTYVLLLNMLIALMSETVNHVADNSWSIWKLQKAISVLEMENGY
WWCRRKKHREGRLLKVGPDERWCFRVEEVNWAAWTLSEDPS
Ligand information
Ligand IDP0T
InChIInChI=1S/C21H30O2/c1-5-6-7-8-16-12-19(22)21(20(23)13-16)18-11-15(4)9-10-17(18)14(2)3/h11-13,17-18,22-23H,2,5-10H2,1,3-4H3/t17-,18+/m0/s1
InChIKeyQHMBSVQNZZTUGM-ZWKOTPCHSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01C(=C)(\C)C1C(C=C(C)CC1)c2c(cc(cc2O)CCCCC)O
OpenEye OEToolkits 2.0.6CCCCCc1cc(c(c(c1)O)C2C=C(CCC2C(=C)C)C)O
CACTVS 3.385CCCCCc1cc(O)c([C@@H]2C=C(C)CC[C@H]2C(C)=C)c(O)c1
OpenEye OEToolkits 2.0.6CCCCCc1cc(c(c(c1)O)[C@@H]2C=C(CC[C@H]2C(=C)C)C)O
CACTVS 3.385CCCCCc1cc(O)c([CH]2C=C(C)CC[CH]2C(C)=C)c(O)c1
FormulaC21 H30 O2
Namecannabidiol;
(1'R,2'R)-5'-methyl-4-pentyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro[1,1'-biphenyl]-2,6-diol
ChEMBLCHEMBL190461
DrugBankDB09061
ZINCZINC000004097406
PDB chain8sly Chain B Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8sly Cannabidiol sensitizes TRPV2 channels to activation by 2-APB.
Resolution3.32 Å
Binding residue
(original residue number in PDB)		L537 F540 L541 Y544
Binding residue
(residue number reindexed from 1)		L442 F445 L446 Y449
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006915 apoptotic process
GO:0008285 negative regulation of cell population proliferation
GO:0009266 response to temperature stimulus
GO:0045773 positive regulation of axon extension
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0090280 positive regulation of calcium ion import
GO:0120162 positive regulation of cold-induced thermogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030424 axon
GO:0032584 growth cone membrane
GO:0042470 melanosome
GO:0044295 axonal growth cone
GO:0044297 cell body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8sly, PDBe:8sly, PDBj:8sly
PDBsum8sly
PubMed37199723
UniProtQ9WUD2|TRPV2_RAT Transient receptor potential cation channel subfamily V member 2 (Gene Name=Trpv2)

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