Structure of PDB 8sgf Chain B Binding Site BS01
Receptor Information
>8sgf Chain B (length=328) Species:
9606
(Homo sapiens) [
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CPAERSGHVAVSDGRHMFVWGGYKSNYDFYLPREELWIYNMETGRWKKIN
TEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLQW
ERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSF
WNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFV
FGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLF
LFGGFTTDKQPLSDAWTYCISKNEWIQFNHPYTEKPRLWHTACASDEGEV
IVFGGCANNLLVHHRAAHSNEILIFSVQ
Ligand information
>8sgf Chain Y (length=6) Species:
9606
(Homo sapiens) [
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NNTSGS
Receptor-Ligand Complex Structure
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PDB
8sgf
Structure-based discovery and characterization of small molecule ligands and PROTAC degraders that co-opt the E3 ligase KLHDC2 for targeted protein degradation
Resolution
1.418 Å
Binding residue
(original residue number in PDB)
Y50 S92 H109 K147 Y163 R189 W191 R236 R241 S269 W270 W321 H345
Binding residue
(residue number reindexed from 1)
Y23 S60 H77 K115 Y131 R157 W159 R204 R209 S237 W238 W289 H313
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:8sgf
,
PDBe:8sgf
,
PDBj:8sgf
PDBsum
8sgf
PubMed
38177675
UniProt
Q9Y2U9
|KLDC2_HUMAN Kelch domain-containing protein 2 (Gene Name=KLHDC2)
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