Structure of PDB 8sg7 Chain B Binding Site BS01

Receptor Information
>8sg7 Chain B (length=426) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQRHENESVYKASLNLIEKYFS
Ligand information
>8sg7 Chain C (length=22) Species: 740950 (Bat adeno-associated virus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PSVKRPHASPDDQPARKRLDFG
Receptor-Ligand Complex Structure
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PDB8sg7 Structural basis for nuclear import of bat adeno-associated virus capsid protein
Resolution2.4 Å
Binding residue
(original residue number in PDB)		S105 W142 N146 S149 G150 T155 Q181 W184 N188 G191 D192 N228 W231 R238 W273 Y277 D280 R315 V321 G323 W357 N361 E396 W399 S406
Binding residue
(residue number reindexed from 1)		S34 W71 N75 S78 G79 T84 Q110 W113 N117 G120 D121 N157 W160 R167 W202 Y206 D209 R244 V250 G252 W286 N290 E325 W328 S335
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8sg7, PDBe:8sg7, PDBj:8sg7
PDBsum8sg7
PubMed38441555
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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