Structure of PDB 8rn8 Chain B Binding Site BS01

Receptor Information

>8rn8 Chain B (length=622) Species: 1601067 (Influenza B virus (B/Memphis/13/2003)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MNINPYFLFIDVPIQAAISTTFPYTGVPPYSHGTGTGYTIDTVIRTHEYS
NKGKQYISDVTGCTMVDPTNGPLPEDNEPSAYAQLDCVLEALDRMDEEHP
GLFQAASQNAMETLMVTTVDKLTQGRQTFDWTVCRNQPAATALNTTITSF
RLNDLNGADKGGLIPFCQDIIDSLDRPEMTFFSVKNIKRIPMKVKDKITK
VEYIKRALSLNTMTKAIATAGIQIRGFVLVVENLAKNICENLEQSGLPVG
GNEKKAKLSNAVAKMLSNCPPGGISMTVTGDNTKWNECLNPRIFLAMTER
ITRDSPIWFRDFCSIAPVLFSNKIARLGKGFMITSKTKRLKAQIPCPDLF
SIPLERYNEETRAKLKKLKPFFNEEGTASLSPGMMMGMFNMLSTVLGVAA
LGIKNIGNKEYLWDGLQSSDDFALFVNAKDEETCMEGINDFYRTCKLLGI
NMSKKKSYCNETGMFEFTSMFYRDGFVSNFAMELPSFGVAGVNESADMAI
GMTIIKNNMINNGMGPATAQTAIQLFIADYRYTYKCHRGDSKVEGKRMKI
IKELWENTKGRDGLLVADGGPNIYNLRNLHIPEIVLKYNLMDPEYKGRLL
HPQNPFVGDYDAVSGTHSWRTK

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

8rn8 Chain B Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8rn8 Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase.
Resolution	2.92 Å
Binding residue (original residue number in PDB)	D445 F446 E490
Binding residue (residue number reindexed from 1)	D421 F422 E466
Annotation score	1

External links

PDB	RCSB:8rn8, PDBe:8rn8, PDBj:8rn8
PDBsum	8rn8
PubMed	39160148
UniProt	Q5V8Y6

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