Structure of PDB 8rih Chain B Binding Site BS01

Receptor Information
>8rih Chain B (length=333) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKIPIWLDCDPGHDDAIAILLGCFHPAFNLLGISTCFGNAPPENTDYNAR
SLLTAMGKAQAIPVYKGAQRPWKREPHYAPDIHGISGLDGTSLLPKPTFE
ARTDKTYIEAIEEAILANNGEISFVSTGALTTLATVFRCKPYLKKSVKYI
SIMGGGLHGLGNCNPNLSAEFNVWIDPDAANYIFRDPDVKDKCIVVPLNL
THKAIATYKVNEMIYNEKNNSKLRELFLELFQFFAHTYGFESGPPIHDPV
ASMPLLEFYGWDPSSAVGFRYKRMDISCIDDVFNENSGKIIIEKEYPNDS
DVGTIIGLDLNIQYFWDQIFEALNRADKMSTIG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8rih Chain B Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8rih Structure-Function Insights into the Dual Role in Nucleobase and Nicotinamide Metabolism and a Possible Use in Cancer Gene Therapy of the URH1p Riboside Hydrolase.
Resolution2.74 Å
Binding residue
(original residue number in PDB)		D13 D18 T130 G131 D255
Binding residue
(residue number reindexed from 1)		D10 D15 T127 G128 D248
Annotation score1
Gene Ontology
Molecular Function
GO:0008477 purine nucleosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0045437 uridine nucleosidase activity
GO:0050263 ribosylpyrimidine nucleosidase activity
GO:0070635 nicotinamide riboside hydrolase activity
GO:0070636 nicotinic acid riboside hydrolase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006152 purine nucleoside catabolic process
GO:0006216 cytidine catabolic process
GO:0006218 uridine catabolic process
GO:0008655 pyrimidine-containing compound salvage
GO:0019358 nicotinate nucleotide salvage
GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway
GO:0046135 pyrimidine nucleoside catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8rih, PDBe:8rih, PDBj:8rih
PDBsum8rih
PubMed39000137
UniProtQ04179|URH1_YEAST Uridine nucleosidase (Gene Name=URH1)

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