Structure of PDB 8rbx Chain B Binding Site BS01

Receptor Information
>8rbx Chain B (length=1112) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAP
PIDLQPPRYLLKFEQIYLSKPTHWDGAPSPMMPNEARLRNLTYSAPLYVD
ITKTVQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGG
YFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTS
TIWVSMLARQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFED
PEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQ
KEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLD
LAGPLLAFLFRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGL
KYSLATGNWGDARAGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQ
LHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSM
ENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNN
YSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHP
SMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHV
LYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSA
VDRGFFRSVFYRSYKEQESKKQEEVFEKPTRETCQGMRHAIYDKLDDDGL
IAPGVRVSGDDVIIGKTVTLPERRYTKRDCSTFLRTSETGIVDQVMVTLN
QEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGIT
PDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKIS
NLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSR
ARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASD
PYQVHVCNLCGIMAIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQEL
MSMSIAPRMMSV
Ligand information
Receptor-Ligand Complex Structure
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PDB8rbx Structural basis of Integrator-dependent RNA polymerase II termination
Resolution4.1 Å
Binding residue
(original residue number in PDB)		Q468 R491 Q731 G839 R841 K934 K942 H1053 R1080
Binding residue
(residue number reindexed from 1)		Q418 R441 Q681 G786 R788 K872 K880 H991 R1018
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8rbx, PDBe:8rbx, PDBj:8rbx
PDBsum8rbx
PubMed38570683
UniProtI3LGP4

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