Structure of PDB 8qz2 Chain B Binding Site BS01

Receptor Information
>8qz2 Chain B (length=246) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCV
SPQELETLIQHALDADNAGVSPIGQSSQQSSHWDLGSAFFFAGTVITTIG
YGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEK
VFVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVT
LTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIG
Ligand information
Ligand IDK
InChIInChI=1S/K/q+1
InChIKeyNPYPAHLBTDXSSS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[K+]
FormulaK
NamePOTASSIUM ION
ChEMBLCHEMBL1233793
DrugBankDB01345
ZINC
PDB chain8qz2 Chain B Residue 600 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8qz2 Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		G174 Y175 G176 G283 F284 G285
Binding residue
(residue number reindexed from 1)		G100 Y101 G102 G205 F206 G207
Annotation score3
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:8qz2, PDBe:8qz2, PDBj:8qz2
PDBsum8qz2
PubMed38755204
UniProtP57789|KCNKA_HUMAN Potassium channel subfamily K member 10 (Gene Name=KCNK10)

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