Structure of PDB 8qqs Chain B Binding Site BS01

Receptor Information
>8qqs Chain B (length=743) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKE
IIVTIHADNSVSVQDDGRVSVVNALSQKLELVIQREGKIHRQIYEHGVPQ
ATGTMVRFWPSLETFTNVTEFEYEILAKRLRELSFLNSGVSIRLRDKRDG
KEDHFHYEGGIKAFVEYLNKNKTPIHPNIFYFSTEKDGIGVEVALQWNDG
FQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKEGYSKKAKVSAT
GDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLAEYL
LENPTDAKIVVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQ
ERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKM
LSSQEVATLITALGCGIGRDEYNPDKLRYHSIIIMTDADVDGSHIRTLLL
TFFYRQMPEIVERGHVYIAQPPLYKVKKGKQEQYIKDDEAMDQYQISIAL
DGATLHTNASAPALAGEALEKLVSEYNATQKMINRMERRYPKAMLKELIY
QPTLTEADLSDEQTVTRWVNALVSELNDKEQHGSQWKFDVHTNAEQNLFE
PIVRVRTHGVDTDYPLDHEFITGGEYRRICTLGEKLRGLLEEDAFIERGE
RRQPVASFEQALDWLVKESRRGLSIQRYKGLGEMNPEQLWETTMDPESRR
MLRVTVKDAIAADQLFTTLMGDAVEPRRAFIEENALKAANIDI
Ligand information
Receptor-Ligand Complex Structure
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PDB8qqs Structural basis of DNA crossover capture by E. coli DNA gyrase
Resolution2.9 Å
Binding residue
(original residue number in PDB)		E424 G425 D426 S427 K447 G448 K449 R457 D502 K740
Binding residue
(residue number reindexed from 1)		E363 G364 D365 S366 K386 G387 K388 R396 D441 K679
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0034335 DNA negative supercoiling activity
GO:0046872 metal ion binding
Biological Process
GO:0006261 DNA-templated DNA replication
GO:0006265 DNA topological change
GO:0006351 DNA-templated transcription
GO:0009410 response to xenobiotic stimulus
GO:0046677 response to antibiotic
GO:0051276 chromosome organization
Cellular Component
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009330 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8qqs, PDBe:8qqs, PDBj:8qqs
PDBsum8qqs
PubMed38603484
UniProtP0AES6|GYRB_ECOLI DNA gyrase subunit B (Gene Name=gyrB)

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