Structure of PDB 8qca Chain B Binding Site BS01

Receptor Information
>8qca Chain B (length=756) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YTAAKYITETYASKPNWQAASSIASRLIKGEKAKAELRSNNWPFRVVGIA
HLEKQEESDSIEWFQSALRVDPNDVESWVGLGQAYHACGRIEASIKVFDK
AIQLRPSHTFAQYFKAISLCDVGEYLESLDILEKVCQEAATEESFQIGLV
EVLMRCSLDLYSQGFLLKSVSIAKDTIERIKIIISELKCENQQVWIYLSQ
VLRLFIWIESKVDTLPVESLVSIFENSEEIDSVDNIKIDTLLDSTTDDNV
SIACKFLILASKYSGTVRASYWYNIGISELTAFITLKEPQYRDAAIFAFK
KSIQLQSNTSETWIGLGIATMDINFRVSQHCFIKATALEPKATNTWFNLA
MLGLKKKDTEFAQQVLNKLQSLAPQDSSPWLGMALILEEQGDIIGSSKLF
AHSFILSNGRSKAAQFMYAKNVLENHINNGDDERDIETVEKLTTASIALE
QFFKKSPDSQFALQCALLTLERLHHYENANELANRLIGILEKKFEKTQDE
RELFNFAIIKGQFARIHLGLGNFELSIENADLSQGIISESSDEKSMKTKI
SNHICLGLSYFFLNDFDQTLNQFQELLSISKDSKHLVVLIAKVLYDVGES
DTKEIALQELTEYIATSGADLLVTLTIAAMSILDDKREDLSIILEELKAL
PLSKQIIDKHKDAPYLIEEITKRLYRNDTGKQVWQRSAYFFPNNLKVWER
LDKNIQRRIASNGQNKVTAEEMSKLYCESKNLRSIQRGMFLCPWNVTAVK
ALNECF
Ligand information
>8qca Chain E (length=23) Species: 4932 (Saccharomyces cerevisiae) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
MSLLEQLARKRIVSLSLKLSALK
Receptor-Ligand Complex Structure
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PDB8qca Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly.
Resolution2.84 Å
Binding residue
(original residue number in PDB)		V882 L908 N915 F1170 F1182 G1211
Binding residue
(residue number reindexed from 1)		V221 L242 N249 F494 F506 G535
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0006401 RNA catabolic process
GO:0006402 mRNA catabolic process
GO:0051607 defense response to virus
GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0055087 Ski complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8qca, PDBe:8qca, PDBj:8qca
PDBsum8qca
PubMed37879335
UniProtP17883|SKI3_YEAST Superkiller protein 3 (Gene Name=SKI3)

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