Structure of PDB 8q3b Chain B Binding Site BS01

Receptor Information
>8q3b Chain B (length=1104) Species: 10498 (African swine fever virus BA71V) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ITYGPIETVDNEELTEADMLSFISAAVNSTGLIGYNIKSFDDLMDNGIPQ
IVKQMFNESVQIQFNFTDVNIERPQHRNYSQGNKINLLPNKARLCGLSYS
GPVNLAAEVILTAHYRASIPPFQVSTFPIMRGSNRCHTHHLSKTAKKEIG
EDPNEPGGYFIARGGEWVVDLLENIRFNTLHIHYHTMQQGNNEIIRGEFI
SQPGGAFENSSQIIIRYMTTGAITIEINSTKFSKLRIPWYLIFRMFGMTG
DDSIIEQVVFDLESNSPVNTFMIEILEKSIHVLDPIFQPVQHEPNREKII
QFLSEKVSKFSDENAVQYLNERQLTILDKILLPHMGQTADTRVRKLRFLG
LLIHKILLVIMNVFPPTDRDSYRTKRVHGSGVSLAKAFKAIFNTSVIAPI
INGFKELLKASDLNRSMEQSIISGNKTNLLNTISALRTVNTHNTTNASKQ
TERADMMRRVHASYPGYICVAQSADTGEKVGMSKQLAITANVCTAGEVLS
LKQRLLSDPAIQQLADVSNKDIVRKGLARVFINGEWIGCCTNAFELAQRY
RMFRREGKIVHPHTTIYWDSMVDEVEFWLDVGRLTRPLLIVDNNIEKYNQ
ACYKAAEARKKGDKDWEKHKIPFIQNTRFTSQMAKDILAGTLTLEDLVAQ
GICEFITPEEAENCLVAFSIIELRKHKHDVTRRFTHVDVPQAILGLAALV
SPYANCTQPARVTYETNQGNRFFQFYNEMPLVKTIAHNYVIPNGLNTIVA
YMIYGGYNQEDSVIVSQSFIDRGGFAGTFYREEKVEGANYEKLVDGFVPV
GTVVKKGDIIIGKDRSVMYGFDEPAVVDAVMRPHGPNDEIFGLMRLRYER
NLNIGDKMSSRSGNKGIAALALPTSDMPFTEDGLQPDLIVNPHSHPSRMT
NGQMIETTVGLANALQGVVTDGTAFLPINVQLLSERLAQEGLRFNGCQKM
FNGQTGEYFDAAIFIGPTYHQRLQKFVLDDRYAVASYGPTDALTGQPLDG
KRSHGGLRLGEMEHWVLTAQGAMQTIIEKSHDDSDGCISYICRNCGEPAI
YNASHPIYKCMNCDVQADIGMVDSRRSSIVFQHEMRAANVNITSVLSPRV
FQPA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8q3b Chain B Residue 1301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8q3b Structural characterization of the fully recombinant RNA polymerase from African Swine Fever Virus
Resolution2.69 Å
Binding residue
(original residue number in PDB)		C1180 C1183 C1201
Binding residue
(residue number reindexed from 1)		C1042 C1045 C1063
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0030430 host cell cytoplasm
GO:0044423 virion component

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8q3b, PDBe:8q3b, PDBj:8q3b
PDBsum8q3b
PubMed38383525
UniProtP42487|RPB2_ASFB7 DNA-directed RNA polymerase RPB2 homolog (Gene Name=Ba71V-053)

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