Structure of PDB 8q26 Chain B Binding Site BS01

Receptor Information

>8q26 Chain B (length=393) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLP
QGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRP
PGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKK
LRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNP
RKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLL
TRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTL
PSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNAL
DLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ

Ligand information

>8q26 Chain F (length=8) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GNCFSKPR

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8q26 HsNMT1 in complex with both MyrCoA and GNCFSKPR inhibitor peptide
Resolution	1.9 Å
Binding residue (original residue number in PDB)	V181 D183 D185 F188 F190 T282 G284 Y296 H298 F311 S405 I469 G470 D471 G472 N473 Q496
Binding residue (residue number reindexed from 1)	V78 D80 D82 F85 F87 T179 G181 Y193 H195 F208 S302 I366 G367 D368 G369 N370 Q393

External links

PDB	RCSB:8q26, PDBe:8q26, PDBj:8q26
PDBsum	8q26
PubMed
UniProt	P30419\|NMT1_HUMAN Glycylpeptide N-tetradecanoyltransferase 1 (Gene Name=NMT1)

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