Structure of PDB 8q0n Chain B Binding Site BS01

Receptor Information
>8q0n Chain B (length=831) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELPEDNETAVYTLMPMVMADQHRSVSELLSNSKFDVNYAFGRVKRSLLHI
AANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYS
ADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVA
CQNGHKTTVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILLLRGA
KYLPDKNGVTPLDLCVQGGYGETCEVLIQYHPRLFQTIIQMTQNEDLREN
MLRQVLEHLSQQSESQYLKILTSLAEVATTNGHKLLSLSSNYDAQMKSLL
RIVRMFCHVFRIGPSSPNKTPRSQVFKPLELLWHSLDEWLVLIATELMKN
KRDSTEITSILLKQASADCQDVISMTANRLSAVIQAFYMCCSCQMPPGMT
SPRFIEFVCKHDEVLKCFVNRNPKIIFDHFHFLLECPELMSRFMHIIKAQ
PFKDRCEWFYEHLHSGQPDSDMVHRPVNENDILLVHRDSIFRSSCEVVSK
ANCAKLKQGIAVRFHGEEGMGQGVVREWFDILSNEIVNPDYALFTQSADG
TTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILG
IPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVP
LKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSL
IQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVED
ITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPT
SSTCINMLKLPEYPSKEILKDRLLVALHCGS
Ligand information
Ligand ID04E
InChIInChI=1S/C2H3IO2/c3-1-2(4)5/h1H2,(H,4,5)
InChIKeyJDNTWHVOXJZDSN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.370OC(=O)CI
OpenEye OEToolkits 1.7.6C(C(=O)O)I
ACDLabs 12.01ICC(=O)O
FormulaC2 H3 I O2
Nameiodoacetic acid
ChEMBLCHEMBL376280
DrugBank
ZINCZINC000003860524
PDB chain8q0n Chain B Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8q0n Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1
Resolution4.2 Å
Binding residue
(original residue number in PDB)		Q594 C876
Binding residue
(residue number reindexed from 1)		Q522 C804
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0031267 small GTPase binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007030 Golgi organization
GO:0016567 protein ubiquitination
GO:0016601 Rac protein signal transduction
GO:0030334 regulation of cell migration
GO:0061025 membrane fusion
GO:0070936 protein K48-linked ubiquitination
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016604 nuclear body
GO:0032580 Golgi cisterna membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8q0n, PDBe:8q0n, PDBj:8q0n
PDBsum8q0n
PubMed38332367
UniProtQ8IYU2|HACE1_HUMAN E3 ubiquitin-protein ligase HACE1 (Gene Name=HACE1)

[Back to BioLiP]