Structure of PDB 8pnq Chain B Binding Site BS01

Receptor Information
>8pnq Chain B (length=744) Species: 1318616 (Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDVNPTLLFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHKYS
EKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP
GIFENSCLETMEIVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RSNGLTANESGRLIDFLKDVMDSMDKEEMEITTHFQRKRRVRDNMTKKMV
TQRTIGKKKQRLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRG
FVYFVEALARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSF
TITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNVLSIAPIMFSNKMAR
LGKGYMFESKSMKLRTQVPAEMLANIDLKYFNKSTREKIEKIRPLLIDGT
ASLSPGMMMGMFNMLSTVLGVSILNLGQKKYTKTTYWWDGLQSSDDFALI
VNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINRTGTFEFTSFFYRYG
FVANFSMELPSFGVSGINESADMSVGVTVIKNNMINNDLGPATAQMALQL
FIKDYRYTYRCHRGDTQIQTRRAFELGKLWEQTRSKAGLLVSDGGPNLYN
IRNLHIPEVCLKWELMDEDYQGRLCNPMNPFVSHKEIDSVSMEYDAVATT
HSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISS
MVEAMVSRARIDARIDFESGRIKKEEFAEIMKICSTIEELRRQK
Ligand information
>8pnq Chain V (length=36) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aguagaaacaaggguguauuuuccccucuuuuugcu
.<<....>>...........................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8pnq The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome.
Resolution2.88 Å
Binding residue
(original residue number in PDB)		Y30 H32 G33 T34 G125 R126 Q127 R135 N136 K198 V200 R203 M227 K229 I241 A242 T243 R249 P272 V273 G274 M356 R365 G410 M414 N532 Y557 R560 I568 Q569 S633 R670 I674 L675 N676 T677
Binding residue
(residue number reindexed from 1)		Y30 H32 G33 T34 G125 R126 Q127 R135 N136 K198 V200 R203 M227 K229 I241 A242 T243 R249 P272 V273 G274 M356 R365 G410 M414 N532 Y557 R560 I568 Q569 S633 R657 I661 L662 N663 T664
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8pnq, PDBe:8pnq, PDBj:8pnq
PDBsum8pnq
PubMed38316757
UniProtM9TLW3

[Back to BioLiP]