Structure of PDB 8pnp Chain B Binding Site BS01

Receptor Information
>8pnp Chain B (length=735) Species: 1318616 (Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDVNPTLLFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHKYS
EKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP
GIFENSCLETMEIVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RSNGLTANESGRLIDFLKDVMDSMDKEEMEITTHGKKKQRLNKRSYLIRA
LTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVEALARSICEKLEQSGL
PVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAM
ITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQVPAE
MLANIDLKYFNKSTREKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGV
SILNLGQKKYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCK
LVGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESA
DMSVGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTR
RAFELGKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQ
GRLCNPMNPFVSHKEIDSVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRN
RSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSR
ARIDARIDFESGRIKKEEFAEIMKICSTIEELRRQ
Ligand information
>8pnp Chain V (length=29) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aguagaaacaaggguccccugcuuuugcu
.<<....>>.<<<<..>>>>.........
Receptor-Ligand Complex Structure
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PDB8pnp The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome.
Resolution2.49 Å
Binding residue
(original residue number in PDB)		H32 T34 R126 R135 N136 D230 I241 A242 R260 L271 M356 R365 M409 M411 N413 P651 N671 R672 S673 N676
Binding residue
(residue number reindexed from 1)		H32 T34 R126 R135 N136 D209 I220 A221 R239 L250 M335 R344 M388 M390 N392 P630 N650 R651 S652 N655
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pnp, PDBe:8pnp, PDBj:8pnp
PDBsum8pnp
PubMed38316757
UniProtS5ME50

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