Structure of PDB 8pk5 Chain B Binding Site BS01

Receptor Information
>8pk5 Chain B (length=495) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTVVVMDVSLSMTRPVSIEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFT
ALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALVGVCNIVQQ
EWGGAIPCQVVLVTDGCLNRFPLPFPFPSKLYIMCMANLEELQSTDSLEC
LERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAVLKCGHL
TADVQVFPRPEPFVVDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRH
LVLPIALNKEGDEVENSANQIAGKIPNFCVLLHGSLKVEGMVAIVQLGPE
WHGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMAQLGPISDAKENPYG
EDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQ
TFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPETAHPDAAFQLTH
AAQQLKLASTGTSEYAAYDQNITPLHTDFSGSDIGVGNLIIDLDA
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8pk5 Chain B Residue 600 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8pk5 Basis of gene-specific transcription regulation by the Integrator complex.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		S10 S12
Binding residue
(residue number reindexed from 1)		S9 S11
Annotation score4
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0016180 snRNA processing
GO:0034243 regulation of transcription elongation by RNA polymerase II
GO:0034472 snRNA 3'-end processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0032039 integrator complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pk5, PDBe:8pk5, PDBj:8pk5
PDBsum8pk5
PubMed38906142
UniProtO15014;
Q96SY0|INT14_HUMAN Integrator complex subunit 14 (Gene Name=INTS14)

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