Structure of PDB 8p4e Chain B Binding Site BS01

Receptor Information
>8p4e Chain B (length=1116) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPI
DLQPPRYLLKFEQIYLSKPTHWDGAPSPMMPNEARLRNLTYSAPLYVDIT
KTVQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGGYF
IINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTI
WVSMLARQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPE
MMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKE
MLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLA
GPLLAFLFRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGLKY
SLATGNWGDARAGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLH
NTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSMEN
LEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSEVS
MIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYS
WQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSM
ILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLY
YPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVD
RGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGMRHAIYDKLDDDG
LIAPGVRVSGDDVIIGKTVTLPENEDRRYTKRDCSTFLRTSETGIVDQVM
VTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTC
EGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNV
QKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDK
IHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLF
EASDPYQVHVCNLCGIMAIANTRTHTYECRGCRNKTQISLVRMPYACKLL
FQELMSMSIAPRMMSV
Ligand information
>8p4e Chain P (length=21) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggacauacauaaagaccaggc
.....................
Receptor-Ligand Complex Structure
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PDB8p4e Structural insights into human co-transcriptional capping.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		A464 G465 Q468 Q731 R834 G839 M840 R841 H842 R890 D891 K934 K942 H1053 P1066 R1080
Binding residue
(residue number reindexed from 1)		A412 G413 Q416 Q679 R782 G787 M788 R789 H790 R832 D833 K876 K884 H995 P1008 R1022
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8p4e, PDBe:8p4e, PDBj:8p4e
PDBsum8p4e
PubMed37369200
UniProtI3LGP4

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