Structure of PDB 8p0k Chain B Binding Site BS01

Receptor Information
>8p0k Chain B (length=1155) Species: 10245 (Vaccinia virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EMDQRLGYKFLVPDPKAGVFYRPLHFQYVSYSNFILHRLHEILTVKRPLL
SFKNNTERIMIEISNVKVTPPDYSPIIASIKGKSYDALATFTVNIFKEVM
TKEGISITKISSYEGKDSHLIKIPLLIGYGNKNPLDTAKYLVPNVIGGVF
INKQSVEKVGINLVEKITTWPKFRVVKPNSFTFSFSSVSPPNVLPTRYRH
YKISLDISQLEALNISSTKTFITVNIVLLSQYLSRVSLEFIRRSLSYDMP
PEVVYLVNAIIDSAKRITESITDFNIDTYINDLVEAEHIKQKSQLTINEF
KYEMLHNFLPHMNYTPDQLKGFYMISLLRKFLYCIFHTSRYPDRDSMVCH
RILTYGKYFETLAHDELENYIGNIRNDIMNNHKNRGTYAVNIHVLTTPGL
NHAFSSLLSGKFKKSDGSYRTHPHYSWMQNISIPRSVGFYPDQVKISKMF
SVRKYHPSQYLYFCSSDVPERGPQVGLVSQLSVLSSITNILTSEYLDLEK
KICEYIRSYYKDDISYFETGFPITIENALVASLNPNMICDFVTDFRRRKR
MGFFGNLEVGITLVRDHMNEIRINIGAGRLVRPFLVVDNGELMMDVCPEL
ESRLDDMTFSDIQKEFPHVIEMVDIEQFTFSNVCESVQKFRMMSKDERKQ
YDLCDFPAEFRDGYVASSLVGINHNSGPRAILGCAQAKQAISCLSSDIRN
KIDNGIHLMYPERPIVISKALETSKIAANCFGQHVTIALMSYKGINQEDG
IIIKKQFIQRGGLDIVTAKKHQVEIPLENFNNKERDRSNAYSKLESNGLV
RLNAFLESGDAMARNISSRTLEDDFARDNQISFDVSEKYTDMYKSRVERV
QVELTDKVKVRVLTMKERRPILGDKFTTRTSQKGTVAYVADETELPYDEN
GITPDVIINSTSIFSRKTISMLIEVILTAAYSAKPYNNKGENRPVCFPSS
NETSIDTYMQFAKQCYEHSNPKLSDEELSDKIFCEKILYDPETDKPYASK
VFFGPIYYLRLRHLTQDKATVRCRGKKTKLIRQANEGRKRGGGIKFGEME
RDCLIAHGAANTITEVLKDSEEDYQDVYVCENCGDIAAQIKGINTCLRCS
KLNLSPLLTKIDTTHVSKVFLTQMNARGVKVKLDFERRPPSFYKPLDKVD
LKPSF
Ligand information
Receptor-Ligand Complex Structure
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PDB8p0k Cryo EM map and model of the vaccinia RNA polymerase intermediate pre-initiation open promoter complex (CASP target)
Resolution2.64 Å
Binding residue
(original residue number in PDB)		Y205 R206 H207 T225 P448 Q450 V451 I453
Binding residue
(residue number reindexed from 1)		Y198 R199 H200 T218 P441 Q443 V444 I446
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001054 RNA polymerase I activity
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006360 transcription by RNA polymerase I
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8p0k, PDBe:8p0k, PDBj:8p0k
PDBsum8p0k
PubMed
UniProtP68694|RP132_VACCC DNA-directed RNA polymerase 133 kDa polypeptide (Gene Name=OPG151)

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