Structure of PDB 8oxo Chain B Binding Site BS01
Receptor Information
>8oxo Chain B (length=1476) Species:
9606
(Homo sapiens) [
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AFVLRDVIYTLIHYINQRSFSLCCDLLSQVCQTAVTYCKDALENHLHVIV
GTLIPLVYEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVF
KDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQL
ELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAV
GSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNT
LVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFRPFE
GLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDF
CQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHCCLDKKSQRTM
LAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAE
IYADKKSMDDQEKRSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSL
YGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQAL
QNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCGTSYHE
SLYNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRL
QAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMAL
RTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIF
QIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAAN
NPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESS
DELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGL
LREHKIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENYINCLLS
GEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAAR
MGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTSSQ
LDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKTQRK
GINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLA
GGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNT
ETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRP
NDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPA
IWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVA
FEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE
TLLTIVEVLLYDPLFDWTMNPFNKVAERVLMRLQEKLKGVEEGTVLSVGG
QVNLLIQQAIDPKNLSRLFPGWKAWV
Ligand information
>8oxo Chain F (length=7) Species:
9606
(Homo sapiens) [
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PPLSQET
Receptor-Ligand Complex Structure
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PDB
8oxo
Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress.
Resolution
3.0 Å
Binding residue
(original residue number in PDB)
H2872 L2900 T2902 F3049 G3051
Binding residue
(residue number reindexed from 1)
H1329 L1357 T1359 F1469 G1471
Enzymatic activity
Enzyme Commision number
2.7.11.1
: non-specific serine/threonine protein kinase.
Gene Ontology
Molecular Function
GO:0003677
DNA binding
GO:0003755
peptidyl-prolyl cis-trans isomerase activity
GO:0004672
protein kinase activity
GO:0004674
protein serine/threonine kinase activity
GO:0004677
DNA-dependent protein kinase activity
GO:0005515
protein binding
GO:0005524
ATP binding
GO:0016301
kinase activity
GO:0016303
1-phosphatidylinositol-3-kinase activity
GO:0035979
histone H2AXS139 kinase activity
GO:0042802
identical protein binding
GO:0044024
histone H2AS1 kinase activity
GO:0044877
protein-containing complex binding
GO:0106310
protein serine kinase activity
Biological Process
GO:0000077
DNA damage checkpoint signaling
GO:0000425
pexophagy
GO:0000723
telomere maintenance
GO:0000724
double-strand break repair via homologous recombination
GO:0000729
DNA double-strand break processing
GO:0001541
ovarian follicle development
GO:0001666
response to hypoxia
GO:0001756
somitogenesis
GO:0002331
pre-B cell allelic exclusion
GO:0002376
immune system process
GO:0006281
DNA repair
GO:0006302
double-strand break repair
GO:0006303
double-strand break repair via nonhomologous end joining
GO:0006338
chromatin remodeling
GO:0006468
protein phosphorylation
GO:0006974
DNA damage response
GO:0006977
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007094
mitotic spindle assembly checkpoint signaling
GO:0007095
mitotic G2 DNA damage checkpoint signaling
GO:0007131
reciprocal meiotic recombination
GO:0007140
male meiotic nuclear division
GO:0007143
female meiotic nuclear division
GO:0007165
signal transduction
GO:0007292
female gamete generation
GO:0007420
brain development
GO:0007507
heart development
GO:0008340
determination of adult lifespan
GO:0008585
female gonad development
GO:0008630
intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009791
post-embryonic development
GO:0010212
response to ionizing radiation
GO:0010506
regulation of autophagy
GO:0010628
positive regulation of gene expression
GO:0016310
phosphorylation
GO:0018105
peptidyl-serine phosphorylation
GO:0030335
positive regulation of cell migration
GO:0030889
negative regulation of B cell proliferation
GO:0032210
regulation of telomere maintenance via telomerase
GO:0032212
positive regulation of telomere maintenance via telomerase
GO:0033151
V(D)J recombination
GO:0033554
cellular response to stress
GO:0034614
cellular response to reactive oxygen species
GO:0035264
multicellular organism growth
GO:0036092
phosphatidylinositol-3-phosphate biosynthetic process
GO:0036289
peptidyl-serine autophosphorylation
GO:0042159
lipoprotein catabolic process
GO:0042770
signal transduction in response to DNA damage
GO:0042981
regulation of apoptotic process
GO:0043065
positive regulation of apoptotic process
GO:0043517
positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043525
positive regulation of neuron apoptotic process
GO:0045141
meiotic telomere clustering
GO:0045785
positive regulation of cell adhesion
GO:0045944
positive regulation of transcription by RNA polymerase II
GO:0046777
protein autophosphorylation
GO:0048538
thymus development
GO:0048599
oocyte development
GO:0051402
neuron apoptotic process
GO:0051726
regulation of cell cycle
GO:0070192
chromosome organization involved in meiotic cell cycle
GO:0071044
histone mRNA catabolic process
GO:0071300
cellular response to retinoic acid
GO:0071479
cellular response to ionizing radiation
GO:0071480
cellular response to gamma radiation
GO:0071481
cellular response to X-ray
GO:0071500
cellular response to nitrosative stress
GO:0080090
regulation of primary metabolic process
GO:0080135
regulation of cellular response to stress
GO:0090398
cellular senescence
GO:0090399
replicative senescence
GO:0097694
establishment of RNA localization to telomere
GO:0097695
establishment of protein-containing complex localization to telomere
GO:1900034
regulation of cellular response to heat
GO:1901796
regulation of signal transduction by p53 class mediator
GO:1903626
positive regulation of DNA catabolic process
GO:1903978
regulation of microglial cell activation
GO:1904262
negative regulation of TORC1 signaling
GO:1904354
negative regulation of telomere capping
GO:1904358
positive regulation of telomere maintenance via telomere lengthening
GO:1904884
positive regulation of telomerase catalytic core complex assembly
GO:2000785
regulation of autophagosome assembly
Cellular Component
GO:0000781
chromosome, telomeric region
GO:0005634
nucleus
GO:0005654
nucleoplasm
GO:0005730
nucleolus
GO:0005737
cytoplasm
GO:0005777
peroxisome
GO:0005782
peroxisomal matrix
GO:0005813
centrosome
GO:0005819
spindle
GO:0005829
cytosol
GO:0005856
cytoskeleton
GO:0031410
cytoplasmic vesicle
GO:0035861
site of double-strand break
GO:0043231
intracellular membrane-bounded organelle
GO:0098850
extrinsic component of synaptic vesicle membrane
GO:1990391
DNA repair complex
View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:8oxo
,
PDBe:8oxo
,
PDBj:8oxo
PDBsum
8oxo
PubMed
37756394
UniProt
Q13315
|ATM_HUMAN Serine-protein kinase ATM (Gene Name=ATM)
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