Structure of PDB 8ov6 Chain B Binding Site BS01

Receptor Information
>8ov6 Chain B (length=156) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLSPLESLAWQVKCLLKYSTTWKPLNPNSWLYHAKLLDPSTPVHILREIG
LRLSHCSHCVPKLEPIPEWPPLASCGVPPFQKPLTSPSRLSRDHATLNGA
LQFATKQLSRTLSRATPIPEGCCCGWLTKTVKETTRTTYSYTDFQKAVNK
LLTASL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8ov6 Chain B Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8ov6 An intramolecular bivalent degrader glues an intrinsic BRD4-DCAF16 interaction
Resolution3.77 Å
Binding residue
(original residue number in PDB)		C100 C179
Binding residue
(residue number reindexed from 1)		C56 C124
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0080008 Cul4-RING E3 ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ov6, PDBe:8ov6, PDBj:8ov6
PDBsum8ov6
PubMed38383787
UniProtQ9NXF7|DCA16_HUMAN DDB1- and CUL4-associated factor 16 (Gene Name=DCAF16)

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