Structure of PDB 8ops Chain B Binding Site BS01

Receptor Information
>8ops Chain B (length=42) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GDRCYNCGGLDHHAKECKLPPQPKKCHFCQSISHMVASCPLK
Ligand information
>8ops Chain C (length=69) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gguaguaauuuguacaguuugagggucuaugauaccacccgguacaggag
auaacuguacaggccacug
........<<<<<<.<<<<.<.............................
.>>>>>.>>>>>>......
Receptor-Ligand Complex Structure
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PDB8ops Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs
Resolution3.82 Å
Binding residue
(original residue number in PDB)		Y140 A149 H162 V171
Binding residue
(residue number reindexed from 1)		Y5 A14 H27 V36
Gene Ontology
Molecular Function
GO:0002151 G-quadruplex RNA binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0031369 translation initiation factor binding
GO:0035198 miRNA binding
GO:0046872 metal ion binding
GO:0070883 pre-miRNA binding
GO:0140517 protein-RNA adaptor activity
GO:1990825 sequence-specific mRNA binding
Biological Process
GO:0007281 germ cell development
GO:0010586 miRNA metabolic process
GO:0010587 miRNA catabolic process
GO:0010629 negative regulation of gene expression
GO:0017148 negative regulation of translation
GO:0019827 stem cell population maintenance
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0031054 pre-miRNA processing
GO:0031123 RNA 3'-end processing
GO:0032008 positive regulation of TOR signaling
GO:0045666 positive regulation of neuron differentiation
GO:0045686 negative regulation of glial cell differentiation
GO:0045727 positive regulation of translation
GO:0048863 stem cell differentiation
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0060964 regulation of miRNA-mediated gene silencing
GO:0071076 RNA 3' uridylation
GO:0071333 cellular response to glucose stimulus
GO:1901724 positive regulation of cell proliferation involved in kidney development
GO:2000632 negative regulation of pre-miRNA processing
GO:2000767 positive regulation of cytoplasmic translation
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0005829 cytosol
GO:0010494 cytoplasmic stress granule

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Cellular Component
External links
PDB RCSB:8ops, PDBe:8ops, PDBj:8ops
PDBsum8ops
PubMed39054354
UniProtQ9H9Z2|LN28A_HUMAN Protein lin-28 homolog A (Gene Name=LIN28A)

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