Structure of PDB 8oki Chain B Binding Site BS01

Receptor Information
>8oki Chain B (length=1101) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DVTPDDLWIVMESYWQEKGLVRQHLDSYNAFIERGLQEVVNEFGGIKPDI
PDFEVKFGKIRVGEPEFQEPHGQRKPLYPMDARIRNLTYAAPLYLEMIPV
IKGVEQDPVEVRIGELPIMLKSKVCRLYGLSDEELIKLGEDPKDPGGYFI
INGSERVIVSIEDIAPNRTLVEKDERQEKYIAKVFSYRHGYRALVAVERR
KDGILYVDIPNVPKPVKFVYVMRALGLERDKDIVEAVGNDPEVQQIMFDN
LEDASDITTQQEALEFIGKLVAPGQAREYRLKRAEYVIDNNLLPHMGVSP
EDRIKKAYYLGMMALKVIELSLGRRPEDDKDHYANKRLRLAGDLLKDLFR
VAFSQLVKDIQYQMTKTYQRKGDKYTFGNIHRFIRNSIRPDVLTERIEHA
LATGAWPGGRTGVSQLLDRTNYMSTLSHLRRVTSPLDREQPHFEARDLHG
THWGRICPTETPEGPNCGLVKNLALMAQITTAVPEEEIREYLMSLGIVPI
EVRRPDPTLWRVYLNGVLIGTIEDGKALVQRIRQDRRSGKISDVINVAYY
EDVKEVYVNSDDGRVRRPLIIVENGVPKLTKEHVQAVKEGRLKWSDLIKM
GIIEYLDAEEEENAYVAMWPWEVTEEHTHLELMPAAILGLPASLVPYPEH
NAAPRNTYGAGMAKQSLGLGWANFRIRVDTRGHLLHYPQIPLVNSRIMKA
VGYEDRPAGQNFVVAVLAYQGYNMEDAIIINKASIERGLARSTFFRTYEA
EEKKYLGGQTDKFEIPDPTVRGYRGEKYYRNLDEDGLIFPESKVEGKDVL
VGRTSPPRFLSLQERRETSVAVRPSEKGVVDKVIITETGDGTKLVKVTVR
DLRIPELGDKFASRHGQKGVIGLIVPQEDMPWTESGIVPDLIVNPHGIPS
RMTVGQLIEAIGGKVASLKGRRVDGTAFIGEPEEKLRKELEELGFKHTGR
EIMYDGITGKRLEADIFIGVIYYQRLHHMVADKIHARSRGPVQVLTKQPT
EGRAREGGLRFGEMERDVLVGHGAAMLLIERLLEESDKTEVWVCENCGHI
ALEDKRRRRVYCPVCGEEERISKVEMSYAFKLLLDELKAMVIRPKLNLSE
R
Ligand information
Receptor-Ligand Complex Structure
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PDB8oki Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment
Resolution3.45 Å
Binding residue
(original residue number in PDB)		Y369 R753 R1018 R1025 M1029
Binding residue
(residue number reindexed from 1)		Y362 R746 R1003 R1010 M1014
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8oki, PDBe:8oki, PDBj:8oki
PDBsum8oki
PubMed38709902
UniProtQ8U0M3

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