Structure of PDB 8oha Chain B Binding Site BS01

Receptor Information

>8oha Chain B (length=336) Species: 267671 (Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130)

GAMTRIAINGFGRIGRLVFRAGIKDPNLEFVAINDLVTPDNLAYLLKYDS
THGRFQGTVEHTEKELIVDGKKILCVSERDPEKLPWKDLKVDYVIESTGL
FTDRVGAEKHIKAGAKKVVISAPAKDKDIPTFVMGVNNEKYNPSNDHIVS
NASCTTNCLAPIVKVVLDNWGIEEGLMTTIHATTATQPTVDGPSKKDFRG
GRGAMQNIIPASTGAAKAVGLCIPEVNGKLTGMSFRVPTPDVSVVDLTVR
TTKETSLKEISAKMKAASEGAMKGILGYTEDMVVSNDFVSSTLSSIFDMD
ACIELNSRFFKLVSWYDNEMGYSNRVLDLIRYMAKK

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 8oha Chain B Residue 410

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8oha The structure of Leptospira interrogans GAPDH sheds light into an immunoevasion factor that can target the anaphylatoxin C5a of innate immunity.
• Resolution: 2.37 Å
• Binding residue (original residue number in PDB): T182 R234
• Binding residue (residue number reindexed from 1): T184 R236
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.2.1.-
  1.2.1.12: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
• GO:0016491 oxidoreductase activity
• GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
• GO:0050661 NADP binding
• GO:0051287 NAD binding

Biological Process

• GO:0006006 glucose metabolic process

External links

• PDB: RCSB:8oha, PDBe:8oha, PDBj:8oha
• PDBsum: 8oha
• PubMed: 37409124
• UniProt: Q72QM3