Structure of PDB 8kgn Chain B Binding Site BS01

Receptor Information
>8kgn Chain B (length=1180) Species: 10497 (African swine fever virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AFEISDFKEHAKKKSMWAGALNKVTISGLMGVFTEDEDLMALPIHRDHCP
ALLKIFDEIIVNATDHERACHNKTKKVTYIKISFDKGVFSCENDGPGIPI
AKHEQASLIAKRDVYVPEVASCHFLAGTNINKAKDCIKGGTNGVGLKLAM
VHSQWAILTTADGAQKYVQHINQRLDIIEPPTITPSREMFTRIELMPVYQ
ELGYAEPLSETEQADLSAWIYLRACQCAAYVGKGTTIYYNDKPCRTGSVM
ALAKMYTLLSAPNSTIHTATIKADAKPYSLHPLQVAAVVSPKFKKFEHVS
VINGVNCVKGEHVTFLKKTINEMVVKKFQQTIKDKNRKTTLRDSCSNIFI
VIVGSIPGIEWTGQRKDELSIAENVFKTHYSIPSSFLTSMTKSIVDILLQ
SISDKYTRARNAGGKRAQDCMLLAAEGDSALSLLRTGLTLGKSNPSGPSF
DFCGMISLGGVIMNACKKVTNITTDSGETIMVRNEQLTNNKVLQGIVQVL
GLDFNCHYKTQEERAKLRYGCIVACVDQDLDGCGKILGLLLAYFHLFWPQ
LIIHGFVKRLLTPLIRVYEKGKTMPVEFYYEQEFDAWAKKQTSLANHTVK
YYKGLAAHDTHEVKSMFKHFDNMVYTFTLDDSAKELFHIYFGGESELRKR
ELCTGVVPLTETQTQSIHSVRRIPCSLHLQVDTKAYKLDAIERQIPNFLD
GMTRARRKILAGGVKCFASNNRERKVFQFGGYVADHMFYHHGDMSLNTSI
IKAAQYYPGSSHLYPVFIGIGSFGSRHLGGKDAGSPRYISVQLASEFIKT
MFPAEDSWLLPYVFEDGQRAEPEYYVPVLPLAIMEYGANPSEGWKYTTWA
RQLEDILALVRAYVDKDNPKHELLHYAIKHKITILPLRPSNYNFKGHLKR
FGQYYYSYGTYVISEQRNIITITELPLRVPTVAYIESIKKSSNRMTFIEE
IIDYSSSETIEILVKLKPNSLNRIVEEFKETEEQDSIENFLRLRNCLHSH
LNFVKPKGGIIEFNTYYEILYAWLPYRRELYQKRLMREHAVLKLRIIMET
AIVRYINESAELNLSHYEDEKEASRILSEHGFPPLNHTLIISPEFASIEE
LNQKALQGCYTYILSLQARELLIAAKTRRVEKIKKMQARLDKVEQLLQES
PFPGASVWLEEIDAVEKAIIKGRNTQWKFH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8kgn Structure of African swine fever virus topoisomerase II in complex with dsDNA
Resolution5.9 Å
Binding residue
(original residue number in PDB)		D440 S441 G472 V473 D543 R705 Q706 T715 H753 A850 N851 P852
Binding residue
(residue number reindexed from 1)		D428 S429 G460 V461 D531 R693 Q694 T703 H741 A838 N839 P840
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
GO:0016853 isomerase activity
GO:0046872 metal ion binding
Biological Process
GO:0000819 sister chromatid segregation
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8kgn, PDBe:8kgn, PDBj:8kgn
PDBsum8kgn
PubMed38816407
UniProtA0A2X0THW2

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