Structure of PDB 8kgm Chain B Binding Site BS01

Receptor Information
>8kgm Chain B (length=1186) Species: 10497 (African swine fever virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AFEISDFKEHAKKKSMWAGALNKVTISGLMGVFTEDEDLMALPIHRDHCP
ALLKIFDEIIVNATDHERACHNKTKKVTYIKISFDKGVFSCENDGPGIPI
AKHEQASLIAKRDVYVPEVASCHFLAGTNINKAKDCIKGGTNGVGLKLAM
VHSQWAILTTADGAQKYVQHINQRLDIIEPPTITPSREMFTRIELMPVYQ
ELGYAEPLSETEQADLSAWIYLRACQCAAYVGKGTTIYYNDKPCRTGSVM
ALAKMYTLLSAPNSTIHTATIKADAKPYSLHPLQVAAVVSPKFKKFEHVS
VINGVNCVKGEHVTFLKKTINEMVVKKFQQTIKDKNRKTTLRDSCSNIFI
VIVGSIPGIEWTGQRKDELSIAENVFKTHYSIPSSFLTSMTKSIVDILLQ
SISKKDNHVDKYTRARNAGGKRAQDCMLLAAEGDSALSLLRTGLTLGKSN
PSGPSFDFCGMISLGGVIMNACKKVTNITTDSGETIMVRNEQLTNNKVLQ
GIVQVLGLDFNCHYKTQEERAKLRYGCIVACVDQDLDGCGKILGLLLAYF
HLFWPQLIIHGFVKRLLTPLIRVYEKGKTMPVEFYYEQEFDAWAKKQTSL
ANHTVKYYKGLAAHDTHEVKSMFKHFDNMVYTFTLDDSAKELFHIYFGGE
SELRKRELCTGVVPLTETQTQSIHSVRRIPCSLHLQVDTKAYKLDAIERQ
IPNFLDGMTRARRKILAGGVKCFASNNRERKVFQFGGYVADHMFYHHGDM
SLNTSIIKAAQYYPGSSHLYPVFIGIGSFGSRHLGGKDAGSPRYISVQLA
SEFIKTMFPAEDSWLLPYVFEDGQRAEPEYYVPVLPLAIMEYGANPSEGW
KYTTWARQLEDILALVRAYVDKDNPKHELLHYAIKHKITILPLRPSNYNF
KGHLKRFGQYYYSYGTYVISEQRNIITITELPLRVPTVAYIESIKKSSNR
MTFIEEIIDYSSSETIEILVKLKPNSLNRIVEEFKETEEQDSIENFLRLR
NCLHSHLNFVKPKGGIIEFNTYYEILYAWLPYRRELYQKRLMREHAVLKL
RIIMETAIVRYINESAELNLSHYEDEKEASRILSEHGFPPLNHTLIISPE
FASIEELNQKALQGCYTYILSLQARELLIAAKTRRVEKIKKMQARLDKVE
QLLQESPFPGASVWLEEIDAVEKAIIKGRNTQWKFH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8kgm Structure of African swine fever virus topoisomerase II in complex with dsDNA
Resolution4.8 Å
Binding residue
(original residue number in PDB)		E438 G439 D440 S441 G472 V473 N496 D543 R705 Q706 T715 H753 A850 N851 P852
Binding residue
(residue number reindexed from 1)		E432 G433 D434 S435 G466 V467 N490 D537 R699 Q700 T709 H747 A844 N845 P846
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
GO:0016853 isomerase activity
GO:0046872 metal ion binding
Biological Process
GO:0000819 sister chromatid segregation
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8kgm, PDBe:8kgm, PDBj:8kgm
PDBsum8kgm
PubMed38816407
UniProtA0A2X0THW2

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