Structure of PDB 8k4l Chain B Binding Site BS01

Receptor Information

>8k4l Chain B (length=178) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

HVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVF
KVFGAAPLENVVRKYKSMILEDLESALASELPPLTIDGIPVSVDKMTQAQ
LRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQ
RVSWTQALRTIVKNCYKQHGREDLLYAF

Ligand information

>8k4l Chain C (length=14) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

atgcgcatgcgcat

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8k4l Crystal structure of NRF1 homodimer in complex with DNA
Resolution	2.1 Å
Binding residue (original residue number in PDB)	T201 Q202 R206 R244 D246 T259
Binding residue (residue number reindexed from 1)	T97 Q98 R102 R140 D142 T155

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006357	regulation of transcription by RNA polymerase II

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Molecular Function

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Biological Process

External links

PDB	RCSB:8k4l, PDBe:8k4l, PDBj:8k4l
PDBsum	8k4l
PubMed	38055835
UniProt	Q16656\|NRF1_HUMAN Nuclear respiratory factor 1 (Gene Name=NRF1)

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