Structure of PDB 8jq6 Chain B Binding Site BS01

Receptor Information

>8jq6 Chain B (length=408) Species: 47715 (Lacticaseibacillus rhamnosus)

MVKPEEVDKAYEVAKQRYAEIGVDTDAAMKELEKVPLSVHCWQGDDIHGF
LFPNYPGIARTPDELAGDMHEALSLIPGKHRVQLHAIYAVTDKKRDLDTL
EPEDFDYWIDWAKQEGVGLDFNGTFFSHPMVKDNMTVSSPDPKVRDFWIR
HGKISREISNYIGEKLGSQVVNNFWLPDGFKDNPIDKKTPRLRLLKALDE
IIKDPLPEKNTIESFEGKLFGTGIESYTTGSHEFYQNYAISRNKLWTIDA
GHFHPTEDVSDKFSAFFPFGKGLFMHVSRPVRWDSDHVVIMDDALIRITR
SLVRDGYLDRTHIGLDFFDATINRVAAWVVGARATQKSLLQAMLAPIDQL
KKDELNADFTTRLIETEELKSFPFGAVWDKFCQDHNTPVGFDWMNNIHQY
EKDVQFKR

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 8jq6 Chain B Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8jq6 X-ray structure and characterization of a probiotic Lactobacillus rhamnosus Probio-M9 L-rhamnose isomerase.
• Resolution: 1.71 Å
• Binding residue (original residue number in PDB): E228 D261 H288 D328
• Binding residue (residue number reindexed from 1): E216 D249 H276 D316
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 5.3.1.14: L-rhamnose isomerase.

Gene Ontology

Molecular Function

• GO:0008740 L-rhamnose isomerase activity
• GO:0016853 isomerase activity
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0019299 rhamnose metabolic process
• GO:0019301 rhamnose catabolic process
• GO:0019324 L-lyxose metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:8jq6, PDBe:8jq6, PDBj:8jq6
• PDBsum: 8jq6
• PubMed: 38430263
• UniProt: A0A171J5T1