Structure of PDB 8jli Chain B Binding Site BS01

Receptor Information
>8jli Chain B (length=586) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEAQRRKEREELAQQYEAILRECGHGRFQWTLYFVLGLALMADGVEVFVV
GFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLL
ISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQ
EKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVF
VLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKG
HPERVFSVTHIKTIGVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFT
MSFSYYGLTVWFPDMIRHLQAVDYASRTKVFPGERVEHVTFNFTLENQIH
RGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVF
YNTDLFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTL
AVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLC
LFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTS
FVGITKAAPILFASAALALGSSLALKLPETRGQVLQ
Ligand information
Ligand IDUKX
InChIInChI=1S/C8H14N2O2/c1-2-6(8(9)12)10-5-3-4-7(10)11/h6H,2-5H2,1H3,(H2,9,12)/t6-/m0/s1
InChIKeyHPHUVLMMVZITSG-LURJTMIESA-N
SMILES
SoftwareSMILES
CACTVS 3.385CC[CH](N1CCCC1=O)C(N)=O
CACTVS 3.385CC[C@H](N1CCCC1=O)C(N)=O
OpenEye OEToolkits 2.0.7CCC(C(=O)N)N1CCCC1=O
OpenEye OEToolkits 2.0.7CC[C@@H](C(=O)N)N1CCCC1=O
FormulaC8 H14 N2 O2
Name(2S)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide;
levetiracetam
ChEMBL
DrugBank
ZINC
PDB chain8jli Chain B Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8jli Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A
Resolution3.38 Å
Binding residue
(original residue number in PDB)		C297 W300 Y462 I663 D670
Binding residue
(residue number reindexed from 1)		C161 W164 Y306 I507 D514
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0019901 protein kinase binding
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006836 neurotransmitter transport
GO:0006874 intracellular calcium ion homeostasis
GO:0007268 chemical synaptic transmission
GO:0014052 regulation of gamma-aminobutyric acid secretion
GO:0016082 synaptic vesicle priming
GO:0055085 transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0030425 dendrite
GO:0030672 synaptic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0031594 neuromuscular junction
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0045202 synapse
GO:0048786 presynaptic active zone
GO:0098793 presynapse
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8jli, PDBe:8jli, PDBj:8jli
PDBsum8jli
PubMed38637505
UniProtQ7L0J3|SV2A_HUMAN Synaptic vesicle glycoprotein 2A (Gene Name=SV2A)

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