Structure of PDB 8jh3 Chain B Binding Site BS01

Receptor Information
>8jh3 Chain B (length=1155) Species: 460519 (Komagataella phaffii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDTITTEDCWTVISAFFEEKGLVSQQLDSFDEFMETSIQDLVWEEPRLIL
DQPAQNINKRYEIRFGKIYLSRPTMTEADGTTHAMFPQEARLRNLTYSSP
VYLDMEKSMFTSIDGNKVHIGKVPIMLRSKFCSLRTLDEVDLYKMKECPY
DMGGYFVINGSEKVLIAQERSAANIVQVFKKAAPSPISHVAEIRSALEKG
SRLISTMQIKLYGREDKGTGRTIKATLPYVKQDIPIVIVFRALGVVPDGE
ILQHICYDENDWQMLEMLKPCIEEGFVIQDKEVALDFIGRRGSAALGIRR
EKRIQYAKDILQKELLPHITQEEGFETRKTFFLGYMVNRLLLCALERKDQ
DDRDHFGKKRLDLAGPLLANLFRILFRKLTREIYRYMQRCIETDRDFNLN
LAVKSTTITSGLKYSLATGNWGEQKKAMSSRAGVSQVLNRYTYSSTLSHL
RRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLLSGI
SIGSPSEPIINFLEEWGMEPLEDYDPAQHTKSTRIFVNGVWTGIHRDPSM
LVSTMRDLRRSGAISPEVSIIRDIREREFKIFTDVGRVYRPLFIVEDDES
KDNKGELRITKEHIRKIQQGYDDDVYGWSSLVTSGVIEYVDGEEEETIMI
AMTPEDLQTRSLNDTAKRIKPEMSTSSHHTFTHCEIHPSMILGVAASIIP
FPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLAKTQ
AMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFR
SYMDQEKRFGISIVEEFEKPTRATTLRLKHGTYEKLDEDGLIAPGVRVSG
DDIIIGKTTPIPPYHTKRDASTPLRSTENGIVDQVLLTTNQEGLKFVKVR
MRTTKVPQIGDKFASRHGQKGTIGVTYRHEDMPFSAEGIVPDLIINPHAI
PSRMTVAHLIECLLSKVGSIRGYEGDATPFTDLTVDAVSNLLRDNGYQSR
GFEVMYNGHTGKKLMAQVFFGPTYYQRLRHMVDDKIHARARGPVQVLTRQ
PVEGRSRDGGLRFGEMERDCMIAHGAAGFLKERLMEASDAFRVHVCGICG
LMSVIANLKKNQFECRSCKNKTNIYQLHIPYAAKLLFQELMAMNIAPRLY
TERSG
Ligand information
Receptor-Ligand Complex Structure
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PDB8jh3 Cryo-EM structures of RNA polymerase II-nucleosome complexes rewrapping transcribed DNA
Resolution3.7 Å
Binding residue
(original residue number in PDB)		A470 G471 Q474 P521 Q776 R884 H887 K979 K987 H1097 R1124
Binding residue
(residue number reindexed from 1)		A432 G433 Q436 P483 Q719 R827 H830 K912 K920 H1030 R1057
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0140727 siRNA-mediated pericentric heterochromatin formation
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0005721 pericentric heterochromatin

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jh3, PDBe:8jh3, PDBj:8jh3
PDBsum8jh3
PubMed37981206
UniProtC4QZQ7

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