Structure of PDB 8jgv Chain B Binding Site BS01

Receptor Information

>8jgv Chain B (length=668) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWSGWLVVT
LTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGKCPQWKTW
AELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPE
IKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCG
NIFSYLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYY
FPLKTLWRSFFAALVAAFVLRSINPFGNSRLVLFYVEYHTPWYLFELFPF
ILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYPVLEVIIVAAITAVIAF
PNPYTRLNTSELIKELFTDCGPLESSSLCDYRAGVGVYSAIWQLCLALIF
KIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFK
EWDCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYTVPLMAAV
MTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRSD
PPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTI
AIESARKVCFALKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTH
NGRLLGIITKKDILRHMA

Ligand information

Ligand ID

ATP

InChI

InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

InChIKey

ZKHQWZAMYRWXGA-KQYNXXCUSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 1.5.0	c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341	Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04	O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0	c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341	Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O

Formula

C10 H16 N5 O13 P3

Name

ADENOSINE-5'-TRIPHOSPHATE

PDB chain

8jgv Chain B Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8jgv Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger.
Resolution	2.98 Å
Binding residue (original residue number in PDB)	H89 L667 A668 Y689 I794 K798 D799
Binding residue (residue number reindexed from 1)	H6 L553 A554 Y575 I657 K661 D662
Annotation score	4

External links

PDB	RCSB:8jgv, PDBe:8jgv, PDBj:8jgv
PDBsum	8jgv
PubMed	39107281
UniProt	P51791\|CLCN3_MOUSE H(+)/Cl(-) exchange transporter 3 (Gene Name=Clcn3)

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