Structure of PDB 8jav Chain B Binding Site BS01

Receptor Information

>8jav Chain B (length=572) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQL
GSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCS
YIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEM
LHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKA
ALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKAC
VVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQ
SVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFH
AERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEA
HDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAI
QIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLF
GEGYSGLEYDYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDA
LEDVSTSPQSTEEVVQSFLISQ

Ligand information

>8jav Chain F (length=7) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

QKRASGQ

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	8jav Molecular basis for C-degron recognition by CRL2 APPBP2 ubiquitin ligase.
Resolution	3.44 Å
Binding residue (original residue number in PDB)	Y338 Y341 Y345 E388 I391 K430 G433 N434 R437 S441 L472 H476 S479 Y483 Y515
Binding residue (residue number reindexed from 1)	Y332 Y335 Y339 E382 I385 K424 G427 N428 R431 S435 L466 H470 S473 Y477 Y509

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:1990756	ubiquitin-like ligase-substrate adaptor activity

	Biological Process
GO:0006886	intracellular protein transport
GO:0015031	protein transport
GO:0016567	protein ubiquitination
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0046907	intracellular transport

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0005875	microtubule associated complex
GO:0016020	membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0031462	Cul2-RING ubiquitin ligase complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:8jav, PDBe:8jav, PDBj:8jav
PDBsum	8jav
PubMed	37844242
UniProt	Q92624\|APBP2_HUMAN Amyloid protein-binding protein 2 (Gene Name=APPBP2)

[Back to BioLiP]