Structure of PDB 8j9v Chain B Binding Site BS01

Receptor Information
>8j9v Chain B (length=778) Species: 10497 (African swine fever virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VDKYTRARNAGGKRAQDCMLLAAEGDSALSLLRTGLTLGKSNPSGPSFDF
CGMISLGGVIMNACKKVTNITTDSGETIMVRNEQLTNNKVLQGIVQVLGL
DFNCHYKTQEERAKLRYGCIVACVDQDLDGCGKILGLLLAYFHLFWPQLI
IHGFVKRLLTPLIRVYEKGKTMPVEFYYEQEFDAWAKKQTSLVNHTVKYY
KGLAAHDTHEVKSMFKHFDNMVYTFTLDDSAKELFHIYFGGESELRKREL
CTGVVPLTETQTQSIHSVRRIPCSLHLQVDTKAYKLDAIERQIPNFLDGM
TRARRKILAGGVKCFASNNRERKVFQFGGYVADHMFYHHGDMSLNTSIIK
AAQYYPGSSHLYPVFIGIGSFGSRHLGGKDAGSPRYISVQLASEFIKTMF
PAEDSWLLPYVFEDGQRAEPEYYVPVLPLAIMEYGANPSEGWKYTTWARQ
LEDILALVRAYVDKDNPKHELLHYAIKHKITILPLRPSNYNFKGHLKRFG
QYYYSYGTYDISEQRNIITITELPLRVPTVAYIESIKKSSNRMTFIEEII
DYSSSETIEILVKLKPNSLNRIVEEFKETEEQDSIENFLRLRNCLHSHLN
FVKPKGGIIEFNSYYEILYAWLPYRRELYQKRLMREHAVLKLRIIMETAI
VRYINESAELNLSHYEDEKEASRILSEHGFPPLNHTLIISPEFASIEELN
QKALQGCYTYILSLQARELLIAAKTRRVEKIKKMQARLDKVEQLLQESPF
PGASVWLEEIDAVEKAIIKGRNTQWKFH
Ligand information
Receptor-Ligand Complex Structure
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PDB8j9v Cryo-EM structure of the African swine fever virus topoisomerase 2 complexed with Cut02aDNA and etoposide (EDI-1)
Resolution2.71 Å
Binding residue
(original residue number in PDB)		V473 N496 R705 Q706 R718 Y751 H753 S761 K793 A850 N851
Binding residue
(residue number reindexed from 1)		V59 N82 R291 Q292 R304 Y337 H339 S347 K379 A436 N437
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0000819 sister chromatid segregation
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8j9v, PDBe:8j9v, PDBj:8j9v
PDBsum8j9v
PubMed38418525
UniProtQ00942|TOP2_ASFB7 DNA topoisomerase 2 (Gene Name=TOP)

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