Structure of PDB 8j8f Chain B Binding Site BS01

Receptor Information
>8j8f Chain B (length=218) Species: 10244 (Monkeypox virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNSVTISHAPYTITYHDDWEPVMSQLVEFYNEVASWLLRDETSPIPDKFF
IQLKQPLRNKRVCVCGIDPYPKDGTGVPFESPNFTKKSIKEIASSISRLT
GVIDYKGYNLNIIDGVIPWNYYLSCKLGETKSHAIYWDKISKLLLQHITK
HVSVLYCLGKTDFSNIRAKLESPVTTIVGYHPAARDHQFEKDRSFEIINV
LLELDNKTPINWAQGFIY
Ligand information
Receptor-Ligand Complex Structure
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PDB8j8f Structural basis of human monkeypox viral DNA replication inhibition by brincidofovir and cidofovir
Resolution2.98 Å
Binding residue
(original residue number in PDB)		K160 T161 Y180 H181 A183
Binding residue
(residue number reindexed from 1)		K160 T161 Y180 H181 A183
Enzymatic activity
Enzyme Commision number 3.2.2.27: uracil-DNA glycosylase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004844 uracil DNA N-glycosylase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:8j8f, PDBe:8j8f, PDBj:8j8f
PDBsum8j8f
PubMed38735603
UniProtQ5IXS4

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