Structure of PDB 8j80 Chain B Binding Site BS01

Receptor Information
>8j80 Chain B (length=288) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ISGWFRSILSDKTSRNLFFFLCLNLSFAFVELLYGIWSNCLGLISDSFHM
FFDSTAILAGLAASVISKWRDNDAFSYGYVRAEVLAGFVNGLFLIFTAFF
IFSEGVERALAPPDVHHERLLLVSILGFVVNLIGIFVFKHGGHGILQGVF
LHILADTLGSIGVIASAIMMQNFGLMIADPICSILIAILIVVSVIPLLRE
SVGILMQRTPPLLENSLPQCYQRVQQLQGVYSLQEQHFWTLCSDVYVGTL
KLIVAPDADARWILSQTHNIFTQAGVRQLYVQIDFAAM
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8j80 Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8j80 Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn 2+ uptake into the Golgi apparatus.
Resolution2.68 Å
Binding residue
(original residue number in PDB)		H70 D74 H164 D244
Binding residue
(residue number reindexed from 1)		H49 D53 H143 D156
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005385 zinc ion transmembrane transporter activity
GO:0008324 monoatomic cation transmembrane transporter activity
GO:0042802 identical protein binding
Biological Process
GO:0006812 monoatomic cation transport
GO:0006829 zinc ion transport
GO:0006882 intracellular zinc ion homeostasis
GO:0055085 transmembrane transport
GO:0071577 zinc ion transmembrane transport
GO:1904257 zinc ion import into Golgi lumen
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0031410 cytoplasmic vesicle
GO:0031982 vesicle
GO:0033017 sarcoplasmic reticulum membrane
GO:0048471 perinuclear region of cytoplasm
GO:1990674 Golgi cis cisterna membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8j80, PDBe:8j80, PDBj:8j80
PDBsum8j80
PubMed37553324
UniProtQ8NEW0|ZNT7_HUMAN Zinc transporter 7 (Gene Name=SLC30A7)

[Back to BioLiP]