Structure of PDB 8j6o Chain B Binding Site BS01

Receptor Information
>8j6o Chain B (length=648) Species: 6100,9606 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PKNVSQKDAEFERTYVDEVNSELVNIYTFNHTVTRNRTEGVRVSVNVLNK
QKGAPLLFVVRQKEAVVSFQVPLILRGMFQRKYLYQKVERTLCQPPTKNE
SEIQFFYVDVSTLSPVNTTYQLRVSRMDDFVLRTGEQFSFNTTAAQPQYF
KYEFPEGVDSVIVKVTSNKAFPCSVISIQDVLCPVYDLDNNVAFIGMYQT
MTKKAAITVQRKDFPSNSFYVVVVVKTEDQACGGSLPFYPFAEDEPVDQG
HRQKTLSVLVSQAVTSEAYVSGMLFCLGIFLSFYLLTVLLACWENWRQTI
AVFYALPVVQLVITYQTVVNVTGNQDICYYNFLCAHPLGNLSAFNNILSN
LGYILLGLLFLLIILQREINHNRALLRNDLCALECGIPKHFGLFYAMGTA
LMMEGLLSACYHVCPNYTNFQFDTSFMYMIAGLCMLKLYQKRHPDINASA
YSAYACLAIVIFFSVLGVVFGKGNTAFWIVFSIIHIIATLLLSTQLYYML
YVDRMVLLVMGNVINWSLAAYGLIMRPNDFASYLLAIGICNLLLYFAFYI
IMKLRSGERIKLIPLLCIVCTSVVWGFALFFFFQGLSTWQKTPAESREHN
RDCILLDFFDDHDIWHFLSSIAMFGSFLVLLTLDDDLDTVQRDKIYVF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8j6o Chain B Residue 903 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8j6o transport T2
Resolution3.25 Å
Binding residue
(original residue number in PDB)		H568 D579 H796 H800
Binding residue
(residue number reindexed from 1)		H412 D423 H612 H616
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0035612 AP-2 adaptor complex binding
GO:0035650 AP-1 adaptor complex binding
GO:0051032 nucleic acid transmembrane transporter activity
GO:0051033 RNA transmembrane transporter activity
Biological Process
GO:0000902 cell morphogenesis
GO:0003323 type B pancreatic cell development
GO:0006091 generation of precursor metabolites and energy
GO:0006401 RNA catabolic process
GO:0008218 bioluminescence
GO:0009749 response to glucose
GO:0042593 glucose homeostasis
GO:0044342 type B pancreatic cell proliferation
GO:0050658 RNA transport
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
Cellular Component
GO:0005575 cellular_component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8j6o, PDBe:8j6o, PDBj:8j6o
PDBsum8j6o
PubMed38664565
UniProtP42212|GFP_AEQVI Green fluorescent protein (Gene Name=GFP);
Q8NBJ9|SIDT2_HUMAN SID1 transmembrane family member 2 (Gene Name=SIDT2)

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