Structure of PDB 8imz Chain B Binding Site BS01

Receptor Information
>8imz Chain B (length=1223) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LDLAASFSAVLTRIQVFVRRLLELHVFKLVALYTVWVALKEVSVMNLLLV
VLWAFALPYPRFRPMASCLSTVWTCIIIVCKMLYQIQNHLQILLLLVFEA
VVYRRQEHYRRQHRQRLDQDLLSCLKYFINFFFYKFGLEICFLMAVNVIG
QRMNFMVILHGCWLVAILTRRRREAIARLWPNYCLFLTLFLLYQYLLCLG
MNSALIKWLYLPPNSTNLISDFLLLLCASQQWQVFSAERTEEWQRGEPNP
IPNFIHCRSYLDMLKVAVFRYLFWLVLVVVFVAGATRISIFGLGYLLACF
YLLLFGTTLLQKDTRAQLVLWDCLILYNVTVIISKNMLSLLSCVFCWVIQ
LFSLIWDSICFFFLLLQRRIFLSHYFLHVSADLKATALQASRGFALYNAA
NLKSINFHRQIEEKSLAQLKRQMKRIRAKQEKYRQSQASDHATVIHSGDY
FLFESDSEEGQATVDGLTRWLRAFTKHHRTMSDVLCAERYLLTQELLRVG
EVRRGVLDQLASELLLDRRLHIPELEEAERFEAQQGRTLRLLRAGYQCVA
AHSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAI
VFTEVMVVTKYLFQFGFFPPPRILGLEKTDSYIKYDLVQLMALFFHRSQL
LCYGLWPLQRFFHDILHTKYRAATDVYALMFLADIVDIIIIIFGFWAFQV
PQAFLFMLLVQFGTMVIDRALYLRKTVLGKLAFQVVLVVAIHIWMFFILP
AVTERMFSQNAVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNH
LNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIK
CSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLIRSV
VGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPQAYEELSQQFDPY
PLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKQELYNGTADIT
LRFTWNFQRDLAKGGTVEYTNEKHTLELAPNSTARRQLAQLLEGRPDQSV
VIPHLFPKYIRAPNGPEANPVKQLQPDEEEDYLGVRIQLRREQVGGTKAS
DFLEWWVIELQDCKADCNLLPMVIFSDKVSPPSLGFLAGYGIVGLYVSIV
LVVGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEE
LYAKLIFLYRSPETMIKWTRERE
Ligand information
>8imz Chain E (length=21) Species: 10090 (Mus musculus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
CCESSDCLEICMECCGICFPS
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8imz MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels.
Resolution3.66 Å
Binding residue
(original residue number in PDB)		H2116 F2120 Q2123 L2127 S2168 R2169 K2184 V2187 M2191 E2495
Binding residue
(residue number reindexed from 1)		H800 F804 Q807 L811 S852 R853 K868 V871 M875 E1171
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005261 monoatomic cation channel activity
GO:0005515 protein binding
GO:0008381 mechanosensitive monoatomic ion channel activity
GO:0042802 identical protein binding
GO:0140135 mechanosensitive monoatomic cation channel activity
Biological Process
GO:0006812 monoatomic cation transport
GO:0010831 positive regulation of myotube differentiation
GO:0033625 positive regulation of integrin activation
GO:0033634 positive regulation of cell-cell adhesion mediated by integrin
GO:0034220 monoatomic ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0050982 detection of mechanical stimulus
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031258 lamellipodium membrane
GO:0032420 stereocilium
GO:0032437 cuticular plate
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0042995 cell projection

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8imz, PDBe:8imz, PDBj:8imz
PDBsum8imz
PubMed37590348
UniProtE2JF22|PIEZ1_MOUSE Piezo-type mechanosensitive ion channel component 1 (Gene Name=Piezo1)

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