Structure of PDB 8ieg Chain B Binding Site BS01

Receptor Information
>8ieg Chain B (length=63) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELANFRTLVYCSLCSKNWKNMAIKTCGHVFCENCCKERLAARMRKCPTCN
KAFSSNDLLTVHL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8ieg Chain B Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8ieg Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A.
Resolution3.44 Å
Binding residue
(original residue number in PDB)		C663 H665 C683 C686
Binding residue
(residue number reindexed from 1)		C26 H28 C46 C49
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity

View graph for
Molecular Function
External links
PDB RCSB:8ieg, PDBe:8ieg, PDBj:8ieg
PDBsum8ieg
PubMed37633270
UniProtQ07457|BRE1_YEAST E3 ubiquitin-protein ligase BRE1 (Gene Name=BRE1)

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