Structure of PDB 8i0b Chain B Binding Site BS01

Receptor Information
>8i0b Chain B (length=261) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYK
LTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDF
SKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKI
AVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQ
RKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKN
KWWYDKGECGE
Ligand information
Ligand IDNXO
InChIInChI=1S/C19H14FNO3S/c20-18-7-2-1-5-16(18)13-8-10-14(11-9-13)17-6-3-4-15-12-21-25(22,23)24-19(15)17/h1-11,21H,12H2
InChIKeyICOQPOKTWUAKMT-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385Fc1ccccc1c2ccc(cc2)c3cccc4CN[S](=O)(=O)Oc34
OpenEye OEToolkits 2.0.7c1ccc(c(c1)c2ccc(cc2)c3cccc4c3OS(=O)(=O)NC4)F
FormulaC19 H14 F N O3 S
Name8-[4-(2-fluorophenyl)phenyl]-3,4-dihydro-1,2$l^{6},3-benzoxathiazine 2,2-dioxide
ChEMBL
DrugBank
ZINC
PDB chain8i0b Chain B Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8i0b Structure of the human GluA2 LBD in complex with LT-102
Resolution1.73 Å
Binding residue
(original residue number in PDB)		P105 S217 K218
Binding residue
(residue number reindexed from 1)		P103 S215 K216
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:8i0b, PDBe:8i0b, PDBj:8i0b
PDBsum8i0b
PubMed
UniProtP42262|GRIA2_HUMAN Glutamate receptor 2 (Gene Name=GRIA2)

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