Structure of PDB 8hzy Chain B Binding Site BS01

Receptor Information

>8hzy Chain B (length=458) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

APAERCAHPGADLGAAVHAVGQTLAAGGLVPPDEAGTTARHLVRLAVRYG
NSPFTPLEEARHDLGVDRDAFRRLLALFGQVPELRTAVETGPAGAYWKNT
LLPLEQRGVFDAALARKPVFPYSVGLYPGPTCMFRCHFCVRVTGARYDPS
ALDAGNAMFRSVIDEIPAGNPSAMYFSGGLEPLTNPGLGSLAAHATDHGL
RPTVYTNSFALTERTLERQPGLWGLHAIRTSLYGLNDEEYEQTTGKKAAF
RRVRENLRRFQQLRAERESPINLGFAYIVLPGRASRLLDLVDFIADLNDA
GQGRTIDFVNIRERAELQEALNAFEERVRERTPGLHIDYGYALNSLRTGA
LRIKPATMRPTAHPQVAVQVDLLGDVYLYREAGFPDLDGATRYIAGRVTP
DTSLTEVVRDFVERGGEVAAVDGDEYFMDGFDQVVTARLNQLERDAADGW
EEARGFLR

Ligand information

Ligand ID

MET

InChI

InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1

InChIKey

FFEARJCKVFRZRR-BYPYZUCNSA-N

SMILES

Software	SMILES
CACTVS 3.341	CSCC[CH](N)C(O)=O
OpenEye OEToolkits 1.5.0	CSCCC(C(=O)O)N
CACTVS 3.341	CSCC[C@H](N)C(O)=O
OpenEye OEToolkits 1.5.0	CSCC[C@@H](C(=O)O)N
ACDLabs 10.04	O=C(O)C(N)CCSC

Formula

C5 H11 N O2 S

Name

METHIONINE

PDB chain

8hzy Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8hzy Mechanistic Insights from the Crystal Structure and Computational Analysis of the Radical SAM Deaminase DesII.
Resolution	2.03979 Å
Binding residue (original residue number in PDB)	G187 G188 L189 E190 P191 Y214 Y242
Binding residue (residue number reindexed from 1)	G178 G179 L180 E181 P182 Y205 Y233
Annotation score	5

External links

PDB	RCSB:8hzy, PDBe:8hzy, PDBj:8hzy
PDBsum	8hzy
PubMed	38943270
UniProt	Q9ZGH1\|DESII_STRVZ dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase (Gene Name=desII)

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