Structure of PDB 8huj Chain B Binding Site BS01

Receptor Information
>8huj Chain B (length=238) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFE
KAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEK
DKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIG
ELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKP
RMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNWV
Ligand information
>8huj Chain C (length=99) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggcugaaggaugcccagaagguaccccauuguaugggaucugaucugggg
ccucggugcacaugcacauguguagucgagguuaaaaaacgucuaggcc
<<<<...<<...<<<<<<.<<...<<<<<...>>>>>..>>..>>>>>>.
<<<<<<.<<<<<<<..>>>>>>>..>>>>>>..........>>..>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8huj Dynamically regulated two-site interaction of viral RNA to capture host translation initiation factor.
Resolution3.76 Å
Binding residue
(original residue number in PDB)		T784 A824 L825 K826 P828 P833 T836 K841 Q848 A914 I915 V921 K925 R954 Q957
Binding residue
(residue number reindexed from 1)		T31 A71 L72 K73 P75 P80 T83 K88 Q95 A161 I162 V168 K172 R201 Q204
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity

View graph for
Molecular Function
External links
PDB RCSB:8huj, PDBe:8huj, PDBj:8huj
PDBsum8huj
PubMed37640715
UniProtQ04637|IF4G1_HUMAN Eukaryotic translation initiation factor 4 gamma 1 (Gene Name=EIF4G1)

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