Structure of PDB 8ht4 Chain B Binding Site BS01

Receptor Information
>8ht4 Chain B (length=390) Species: 196627 (Corynebacterium glutamicum ATCC 13032) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
STLETWPQVIINTYGTPPVELVSGKGATVTDDQGNVYIDLLAGIAVNALG
HAHPAIIEAVTNQIGQLGHVSNLFASRPVVEVAEELIKRFSLDDATLAAQ
TRVFFCNSGAEANEAAFKIARLTGRSRILAAVHGFHGRTMGSLALTGQPD
KREAFLPMPSGVEFYPYGDTDYLRKMVETNPTDVAAIFLEPIQGETGVVP
APEGFLKAVRELCDEYGILMITDEVQTGVGRTGDFFAHQHDGVVPDVVTM
AKGLGGGLPIGACLATGRAAELMTPGKHGTTFGGNPVACAAAKAVLSVVD
DAFCAEVARKGELFKELLAKVDGVVDVRGRGLMLGVVLERDVAKQAVLDG
FKHGVILNAPADNIIRLTPPLVITDEEIADAVKAIAETIA
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain8ht4 Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8ht4 Structural and functional characterization of acetylornithine aminotransferase from corynebacterium glutamicum
Resolution2.51 Å
Binding residue
(original residue number in PDB)		S109 G110 A111 F136 H137 E191 D224 V226 Q227 K253
Binding residue
(residue number reindexed from 1)		S108 G109 A110 F135 H136 E190 D223 V225 Q226 K252
Annotation score1
Enzymatic activity
Enzyme Commision number 2.6.1.11: acetylornithine transaminase.
Gene Ontology
Molecular Function
GO:0003992 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0042802 identical protein binding
Biological Process
GO:0006525 arginine metabolic process
GO:0006526 L-arginine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ht4, PDBe:8ht4, PDBj:8ht4
PDBsum8ht4
PubMed37230944
UniProtQ59282|ARGD_CORGL Acetylornithine aminotransferase (Gene Name=argD)

[Back to BioLiP]