Structure of PDB 8hr0 Chain B Binding Site BS01

Receptor Information
>8hr0 Chain B (length=729) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EGLRVVNLLQERNMLPSTPLKPPVPNLHEDIQKLNCNPELFRCTLTSIPQ
TQALLNKAKLPLGLLLHPFKDLVQLPVVTSSTIVRCRSCRTYINPFVSFL
DQRRWKCNLCYRVNDVPEEEPHRRPEVQNATIEFMAPSEYMLRPPQPPVY
LFVFDVSHNAVETGYLNSVCQSLLDNLDLLPGNTRTKIGFITFDSTIHFY
GLQESLSQPQMLIVSDIEDVFIPMPENLLVNLNESKELVQDLLKTLPQMF
TKTLETQSALGPALQAAFKLMSPTGGRMSVFQTQLPTLGVGALKPREEPN
HRSSAKMTPSTDFYKKLALDCSGQQVAVDLFLLSGQYSDLASLGCISRYS
AGSVYYYPSYHHQHNPVQVQKLQKELQRYLTRKIGFEAVMRIRCTKGLSI
HTFHGNFFVRSTDLLSLPNVNPDAGYAVQMSVEESLTDTQLVSFQSALLY
TSSKGERRIRVHTLCLPVVSTLNDVFLGADVQAISGLLANMAVDRSMTAS
LSDARDALVNAVIDSLSAYRSSVPGLMVPFSLRLFPLFVLALLKQKSFQT
GTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRT
IPQPPILQLSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNY
ASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMKAN
FLQNMIEDRTESALSYYEFLLHIQQQVNK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8hr0 Tighter ER retention of SARS-CoV-2 Omicron spike caused by a constellation of folding disruptive mutations
Resolution3.34 Å
Binding residue
(original residue number in PDB)		R430 Y437 R750 R752 A806 L808
Binding residue
(residue number reindexed from 1)		R85 Y92 R391 R393 A447 L449
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Cellular Component
GO:0030127 COPII vesicle coat

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hr0, PDBe:8hr0, PDBj:8hr0
PDBsum8hr0
PubMed
UniProtO95486|SC24A_HUMAN Protein transport protein Sec24A (Gene Name=SEC24A)

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