Structure of PDB 8hq1 Chain B Binding Site BS01

Receptor Information

>8hq1 Chain B (length=486) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLK
TRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSG
SQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIIS
DKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGA
CLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLTQD
SQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDG
YSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGN
CGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRT
LNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSS
KEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHN

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

8hq1 Chain B Residue 804 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8hq1 Structure Of Human Lgi1-Adam22 Complex In Space Group C2
Resolution	4.17 Å
Binding residue (original residue number in PDB)	D511 I512 E514 N526 I527
Binding residue (residue number reindexed from 1)	D279 I280 E282 N294 I295
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity

	Biological Process
GO:0006508	proteolysis

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Molecular Function

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Biological Process

External links

PDB	RCSB:8hq1, PDBe:8hq1, PDBj:8hq1
PDBsum	8hq1
PubMed
UniProt	Q9P0K1\|ADA22_HUMAN Disintegrin and metalloproteinase domain-containing protein 22 (Gene Name=ADAM22)

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