Structure of PDB 8hke Chain B Binding Site BS01

Receptor Information
>8hke Chain B (length=647) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVLVFEISSKMKMIEKKLEANTVHVLRLELDQSFILDLTKVAAEIVDSSK
YSKEDGVILEVTVSNGRDSFLLKLPTVYPNLKLYTDGKLLNPLVEQDFHF
HQNLIVTVQSRLNADIDYRLHVTHLDRAQYDFLKFKTGQTTKTLSNQKLT
FVKPIGFFLNCSEQNISQFHVTLYSEDDICANLITVPANESIYDRSVISD
KTHNRRVLSFTKRADIFFTETEISMFKSFRIFVFIAPDDSGCSTNTSRKS
FNEKKKISFEFKKLENQSYAVPTALMMIFLTTPCLLFLPIVINIIKNSRS
LHGQMLQYPVAIILPVLMHTAIEFHKWTTSTMANRDEMCFHNHACARPLG
ELRAWNNIITNIGYTLYGAIFIVLSICRRGSHVFGTYECTLLDVTIGVFM
VLQSIASATYHICPSDVAFQFDTPCIQVICGLLMVRQWFVRHESPSPAYT
NILLVGVVSLNFLISAFSKTSYVRFIIAVIHVIVVGSICLAKERSLGSEK
LKTRFFIMAFSMGNFAAIVMYLTLSAFHLNQIATYCFIINCIMYLMYYGC
MKVLHSERITSKAKLCGALSLLAWAVAGFFFFQDDTDWTRSAAASRALNK
PCLLLGFFGSHDLWHIFGALAGLFTFIFVSFVDDDLINTRKTSINIF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8hke Chain B Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8hke dsRNA transporter
Resolution3.71 Å
Binding residue
(original residue number in PDB)		H540 D551 H740 H744
Binding residue
(residue number reindexed from 1)		H411 D422 H611 H615
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:8hke, PDBe:8hke, PDBj:8hke
PDBsum8hke
PubMed38664565
UniProtQ9GZC8|SID1_CAEEL Systemic RNA interference defective protein 1 (Gene Name=sid-1)

[Back to BioLiP]