Structure of PDB 8hb2 Chain B Binding Site BS01

Receptor Information
>8hb2 Chain B (length=255) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KHVNYKVFIYDHIRQIAIPTTNLNSQSSLEDIIDESTSCQSVSTDGSIEI
DGLTLIHNFLSESEESKILNMIDTVKWAKSKSGRRKQDYGPKVNFKHKKV
KTDTFVGMPEYADMLLNKMSEYDVKKLGNYQPFEMCNLEYEEVKKSAIEM
HQDDMWIWGNRLISINLINGSVMTLSNDNKSFLCYVHMPHRSLLCMADEC
RYDWKHGVLAHHIRGRRIALTMREAAKDFAEGGELYEKYGAELIRLGNIR
VPLSK
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain8hb2 Chain B Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8hb2 Structural Basis of Nucleic Acid Recognition and 6mA Demethylation by Caenorhabditis elegans NMAD-1A.
Resolution3.06 Å
Binding residue
(original residue number in PDB)		H184 D186 H239
Binding residue
(residue number reindexed from 1)		H151 D153 H206
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.11.51: DNA N(6)-methyladenine demethylase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0032451 demethylase activity
GO:0035516 broad specificity oxidative DNA demethylase activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
GO:0141131 DNA N6-methyladenine demethylase activity
Biological Process
GO:0006260 DNA replication
GO:0010032 meiotic chromosome condensation
GO:0060903 positive regulation of meiosis I
GO:0070988 demethylation
GO:1901046 positive regulation of egg-laying behavior
GO:1905516 positive regulation of fertilization
GO:2000781 positive regulation of double-strand break repair
GO:2001252 positive regulation of chromosome organization
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hb2, PDBe:8hb2, PDBj:8hb2
PDBsum8hb2
PubMed38255759
UniProtQ8MNT9|NMAD1_CAEEL DNA N6-methyl adenine demethylase (Gene Name=nmad-1)

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