Structure of PDB 8hag Chain B Binding Site BS01

Receptor Information
>8hag Chain B (length=91) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKGGAARHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKV
FLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFG
Ligand information
>8hag Chain J (length=147) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
catcaatatccacctgcagattctaccaaaagtgtatttggaaactgctc
catcaaaaggcatgttcagctgaattcagctgaacatgccttttgatgga
gcagtttccaaatacacttttggtagaatctgcaggtggatattgat
Receptor-Ligand Complex Structure
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PDB8hag Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		R17 R19 R35 R45 I46 G48 R78 K79 T80
Binding residue
(residue number reindexed from 1)		R7 R9 R25 R35 I36 G38 R68 K69 T70
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0032200 telomere organization
GO:0045653 negative regulation of megakaryocyte differentiation
GO:0061644 protein localization to CENP-A containing chromatin
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000786 nucleosome
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0043505 CENP-A containing nucleosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hag, PDBe:8hag, PDBj:8hag
PDBsum8hag
PubMed37460559
UniProtP62805|H4_HUMAN Histone H4 (Gene Name=H4C1)

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