Structure of PDB 8h26 Chain B Binding Site BS01

Receptor Information
>8h26 Chain B (length=175) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKLERILPFSKTLIKQHITPESIVVDATCGNGNDTLFLAEQVPEGHVYGF
DIQDLALENTRDKVKDFNHVSLIKDGHENIEHHINDAHKGHIDAAIFNLG
IVTKPDTTIQAINSLLSLMSIEGIIVLVIYHGQIEKHALLDYLSTLDQKH
AQVLQYQFLNQRNHAPFICAIEKIS
Ligand information
Ligand IDSAH
InChIInChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
InChIKeyZJUKTBDSGOFHSH-WFMPWKQPSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CCSC[CH]1O[CH]([CH](O)[CH]1O)n2cnc3c(N)ncnc23)C(O)=O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)CSCCC(C(=O)O)N)O)O)N
CACTVS 3.341N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23)C(O)=O
ACDLabs 10.04O=C(O)C(N)CCSCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CSCC[C@@H](C(=O)O)N)O)O)N
FormulaC14 H20 N6 O5 S
NameS-ADENOSYL-L-HOMOCYSTEINE
ChEMBLCHEMBL418052
DrugBankDB01752
ZINCZINC000004228232
PDB chain8h26 Chain B Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8h26 Crystal structure of MnmM from S. aureus complexed with SAH (1.50 A)
Resolution1.5 Å
Binding residue
(original residue number in PDB)		T28 C29 N33 D51 I52 Q53 G76 H77 N98
Binding residue
(residue number reindexed from 1)		T28 C29 N33 D51 I52 Q53 G76 H77 N98
Annotation score5
Enzymatic activity
Enzyme Commision number 2.1.1.61: tRNA 5-(aminomethyl)-2-thiouridylate-methyltransferase.
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
Biological Process
GO:0008033 tRNA processing
GO:0032259 methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8h26, PDBe:8h26, PDBj:8h26
PDBsum8h26
PubMed
UniProtQ2FXG9|MNMM_STAA8 tRNA (mnm(5)s(2)U34)-methyltransferase (Gene Name=mnmM)

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