Structure of PDB 8h0i Chain B Binding Site BS01

Receptor Information
>8h0i Chain B (length=345) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPGHMDPDTFSYNFNNRPILSRRNTVWLCYEVERLDNGTWVKMDQHRGQV
YSELKYHPEMRFLSLVSKWKLHRDQEYEVTWYISWSPCTKCARDMATFLQ
ENTHVTLTIFVARLYYFWDPDYQEALRSLAQAGATIKIMNYDEFQHCWSK
FVYSQGAPFQPWDGLDEYSQALSGMLGEILRHSMDPPTFTFNFNNERHET
YLCYEVERMHNDTWVKLNQRRGFLANQRHAELCFLDVIPFWKLDLDQDYR
VTCFTSWSPCFSCAQEMAKFISKNKHVSLCIKTARIYQEGLRTLAEAGAK
ISIMTYSEFKHCWDTFVDHQGAPFQPWDGLDEHSQDLSGRLRAIL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8h0i Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		H0 Y8 N9 R13 I15 L16 S17 R18 N20 T21 S48 E49 H53 W81 Y111 Y112 W114 K253
Binding residue
(residue number reindexed from 1)		H4 Y12 N13 R17 I19 L20 S21 R22 N24 T25 S52 E53 H57 W85 Y115 Y116 W118 K242
Enzymatic activity
Enzyme Commision number 3.5.4.38: single-stranded DNA cytosine deaminase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:8h0i, PDBe:8h0i, PDBj:8h0i
PDBsum8h0i
PubMed37419875
UniProtQ9HC16|ABC3G_HUMAN DNA dC->dU-editing enzyme APOBEC-3G (Gene Name=APOBEC3G)

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